Phebalosin
Phebalosin displays 50% effective concentrations (EC(50)) of 14.1 microg/mL against axenic amastigote forms of Leishmania panamensis. It also displays cytotoxicity (IC(50)) at concentrations of 20.7 microg/mL on human promonocytic U-937 cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Nat Prod. 2010 May 28;73(5):1012-4.
Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis.[Pubmed:
20423106]
METHODS AND RESULTS:
Two new coumarin compounds (1 and 2), Phebalosin (3), its derived artifact murralongin (4), and murrangatin acetonide (5) were isolated from the leaves of Galipea panamensis. The structures of 1 and 2 were assigned as 7-{[(2R*)-3,3-dimethyloxiran-2-yl]methoxy}-8-[(2R*,3R*)-3-isopropenyloxiran-2-yl]-2H-chromen-2-one and 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, respectively, on the basis of their spectroscopic data (primarily NMR and MS).
CONCLUSIONS:
Compounds 1-3 were tested against axenic amastigote forms of Leishmania panamensis and displayed 50% effective concentrations (EC(50)) of 9.9, 10.5, and 14.1 microg/mL, respectively. These three compounds also displayed cytotoxicity (IC(50)) at concentrations of 9.7, 33.0, and 20.7 microg/mL, respectively, on human promonocytic U-937 cells.
Zhong Yao Cai. 2013 May;36(5):744-6.
Study on the chemical constituents from ethyl acetate extract of Micromelum falcatum.[Pubmed:
24218965]
To study the chemical constituents from ethyl acetate extract of Micromelum falcatum.
METHODS AND RESULTS:
The constituents were separated and purified by silica gel, Sephadex LH-20 and HPLC. Their structures were elucidated by spectral analysis (NMR, MS).
Ten compounds were isolated and identified as micropubescin (1), Phebalosin (2), scopoletin (3), citrubuntin (4), thamnosmonin (5), hopeyhopin (6), arnottinin (7), casegravol (8), 2-methoxy-5-hydroxy cinnamate (9), threo-syringoylglycerol (10).
CONCLUSIONS:
Compounds 1 - 10 are obtained from this plant for the first time.
