Paprazine

Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(8):1654-1661.

Chemical constituents from roots of Datura metel.[Pubmed: 29751713]

To study the flavonoids of Scutellaria baicalensis and their bioactivities.
METHODS AND RESULTS:
Chromatographic methods were used to separate compounds, spectral methods were used to determine the structures and bioactivities of the flavonoids were screened in several models in vitro. Nine compounds were isolated and identified as baicalein (1), wogonin (2), oroxylin A (3), 5, 7, 2', 6'-tetrahydroxyflavone (4), viscidulin III (5), baicalin (6), wogonoside (7), oroxylin A-7-O-beta-D-glucuronide (8) and chrysin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (9).
CONCLUSIONS:
Baicalein had good anti-bacteria activity, and some compounds showed inhibiting activity against IL-1beta converting enzyme. The 13C NMR data of compounds 9 were assigned correctly by 2D nuclear magnetic resonance (NMR).

Nat Prod Res. 2009;23(15):1416-23.

Alkaloids from Piper sarmentosum and Piper nigrum.[Pubmed: 19809914 ]

Detailed chemical studies on the roots of Piper sarmentosum and Piper nigrum have resulted in several alkaloids.
METHODS AND RESULTS:
The roots of P. sarmentosum gave a new aromatic compound, 1-nitrosoimino-2,4,5-trimethoxybenzene (1). Piper nigrum roots gave pellitorine (2), (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (3), 2,4-tetradecadienoic acid isobutyl amide (4), piperine (5), sylvamide (6), cepharadione A (7), piperolactam D (8) and Paprazine (9). Structural elucidation of these compounds was achieved through NMR and MS techniques.
CONCLUSIONS:
Cytotoxic activity screening of the plant extracts indicated some activity.