Palbinone

Phytother Res. 2014 Feb;28(2):308-11.

Palbinone from Paeonia suffruticosa protects hepatic cells via up-regulation of heme oxygenase-1.[Pubmed: 23595773]

Paeonia suffruticosa has been traditionally employed for vitalizing blood circulation and alleviating liver and inflammatory diseases.
METHODS AND RESULTS:
The pathways by which Palbinone (PB) isolated from P. suffruticosa mediates heme oxygenase-1 (HO-1) induction were investigated using the specific inhibitors for PI3K and mitogen activated protein kinases pathways. The effect of Palbinone -treatment on Nrf2 translocalization and HO-1-antioxidant response element (ARE) regulation was examined employing Western blot and luciferase assays. Palbinone induced HO-1 expression via the activation of Nrf2 in the hepatic cells, and ARE-dependent genes were stimulated via the Palbinone -mediated Nrf2 activation. Palbinone -mediated HO-1 expression could be involved with PI3K/Akt and ERK1/2 pathways.
CONCLUSIONS:
Our study suggests the mechanism by which Palbinone induces HO-1 expression in the hepatic cells. This might substantiate the traditional applications of P. suffruticosa for the treatment of oxidative stress-related diseases including oxidant and inflammatory-mediated vascular and liver diseases.

Chem Pharm Bull (Tokyo). 1993 Mar;41(3):487-90.

Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase.[Pubmed: 8477499]

METHODS AND RESULTS:
Palbinone, a novel terpenoid isolated from the roots of Paeonia albiflora, showed a strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) of rat liver cytosol.
CONCLUSIONS:
The structures of Palbinone and a known compound, paeonilactone-B isolated from the active fraction of this plant were determined by the use of 2D NMR techniques (1H-1H COSY, 1H-13C COSY, 1H-13C long-range COSY, and HMBC).