Norarecoline Hydrochloride

Norarecoline Hydrochloride
Product Name Norarecoline Hydrochloride
CAS No.: 6197-39-3
Catalog No.: CFN93318
Molecular Formula: C7H12ClNO2
Molecular Weight: 177.62 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The fruits of Areca catechu
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Norarecoline is a muscarinic agonist.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Biochem Systematics and Ecology2017, 11-18
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Pharmaceuticals (Basel).2024, 17(4):462.
  • Food Science and Biotechnology2015, 2205-2212
  • Biomed Pharmacother.2024, 171:116166.
  • Cell Biochem Funct.2018, 36(6):303-311
  • Scientific World Journal.2014, 2014:654193
  • Food Res Int.2021, 148:110607.
  • Molecules.2023, 28(13):4907.
  • Industrial Crops and Products2019, 140:111612
  • Malic acid

    Catalog No: CFN90558
    CAS No: 6915-15-7
    Price: $30/20mg
    Jujuboside D

    Catalog No: CFN98103
    CAS No: 194851-84-8
    Price: $360/10mg
    Silydianin

    Catalog No: CFN90242
    CAS No: 29782-68-1
    Price: $168/20mg
    Kirenol

    Catalog No: CFN98867
    CAS No: 52659-56-0
    Price: $50/20mg
    Betaine

    Catalog No: CFN99546
    CAS No: 107-43-7
    Price: $30/20mg
    Arzneimittelforschung. 1989 May;39(5):539-44.
    Synthesis and muscarinic activity of a series of tertiary and quaternary N-substituted guvacine esters structurally related to arecoline and arecaidine propargyl ester.[Pubmed: 2757669]
    A series of tertiary and quaternary N-substituted guvacine (1,2,5,6-tetrahydro-3-carboxy-pyridine) methyl and propargyl esters have been synthesized and tested for muscarinic/antimuscarinic activity on rat ileum and electrically paced left atria.
    METHODS AND RESULTS:
    Arecoline and arecaidine propargyl ester (APE) as well as their corresponding N-demethyl derivatives, guvacoline (norarecoline, Norarecoline Hydrochloride) and guvacine propargyl ester, acted as full agonists at both atrial and ileal muscarinic receptors (range of pD2-values 6.09-8.07). However, in both preparations arecoline and APE were clearly more potent (up to 15-fold) than their N-demethyl analogues. Replacement of the N-methyl group in arecoline and APE by larger substituents (ethyl, n-propyl, n-butyl, benzyl, phenylethyl) as well as N-methylation resulted in a decrease or even a complete loss of agonistic activity. In both organs, the propargyl esters usually showed higher potency than the corresponding methyl ester analogues.
    CONCLUSIONS:
    N-Ethylguvacine propargyl ester and APE methiodide displayed pronounced agonistic activity in the atria (pD2 approximately 6.5; intrinsic activity = 0.79 and 0.67, respectively) but behaved as competitive antagonists in the ileum (pA2 = 6.06 and 5.62, respectively). Beside the lower sensitivity to muscarinic agonists of the rat ileum as compared to rat atria, the cardioselective stimulant action of both agents may also be due to their ability to recognize structural differences between atrial M2 alpha and ileal M2 beta muscarinic receptor subtypes.
    Drug Des Discov. 1993;9(3-4):237-50.
    Conformational aspects of the muscarinic receptor interactions of bicyclic isoxazole ester bioisosteres of arecoline.[Pubmed: 8400005]

    METHODS AND RESULTS:
    3-Methoxy-4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridine (O-Me-THPO) and O,5-di-Me-THPO are conformationally restricted bioisosteres of the muscarinic agonists norarecoline(Norarecoline Hydrochloride ) and arecoline, respectively, showing partial agonist effects at muscarinic acetylcholine receptors. The 7-membered ring analogue of O-Me-THPO, 3-methoxy-5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepine (O-Me-THAO), shows higher affinity for muscarinic receptor sites than O-Me-THPO or O,5-di-Me-THPO. Similarly, O-Et-THAO binds much more tightly to muscarinic receptor sites than its 6-membered ring analogues, O-Et-THPO and O-Et-5-Me-THPO. Based on receptor binding data, O-Me-THPO and O-Me-THAO, and O-Et-THPO and O-Et-THAO, respectively, show similar degrees of partial agonism. They also show similar relative affinities for muscarinic M1 and M2 receptor sites. Using the semiempirical quantum mechanics programme, AM1, and the molecular mechanics programme, SYBYL, we have studied the conformational flexibility of the O-alkyl-THPO and O-alkyl-THAO ring systems.
    CONCLUSIONS:
    As expected, the 7-membered ring of the latter system was shown to be markedly more flexible than the piperidine rings of O-alkyl-THPO analogues. On the basis of this analysis, a common pharmacophore for these two classes of compounds was constructed.
    Buddlenoid A

    Catalog No: CFN95025
    CAS No: 142750-32-1
    Price: $368/5mg
    Secologanic acid

    Catalog No: CFN95028
    CAS No: 60077-46-5
    Price: $318/20mg
    Lucidumol A

    Catalog No: CFN95059
    CAS No: 217476-73-8
    Price: $318/5mg
    1,4-Dihydroxy-2-carbomethoxy-3-prenylnaphthalene-1-O-beta-glucopyranoside

    Catalog No: CFN95100
    CAS No: 1415729-43-9
    Price: $318/10mg
    Physalin G

    Catalog No: CFN95104
    CAS No: 76045-38-0
    Price: $388/5mg
    Pilosidine

    Catalog No: CFN95110
    CAS No: 229971-57-7
    Price: $413/5mg
    Elgonica dimer A

    Catalog No: CFN95445
    CAS No: 132210-48-1
    Price: $368/5mg
    10-Deacetylcephalomannine

    Catalog No: CFN95519
    CAS No: 76429-85-1
    Price: $318/10mg
    Bayin

    Catalog No: CFN95539
    CAS No: 3681-96-7
    Price: $318/5mg
    Calleryanin

    Catalog No: CFN95556
    CAS No: 20300-53-2
    Price: $318/5mg