Neogambogic acid

Neogambogic acid
Product Name Neogambogic acid
CAS No.: 93772-31-7
Catalog No.: CFN90175
Molecular Formula: C38H46O9
Molecular Weight: 646.77 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Yellow cryst.
Targets: Bcl-2/Bax | Caspase | P450 (e.g. CYP17)
Source: The herbs of Garcinia hanburyi Hook. f.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $258/20mg
Neogambogic acid , an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Cell Death Differ.2021, 1-8.
  • Jurnal Ilmu Pertanian Indonesia2023, 28(4):525-533.
  • Molecules.2020, 25(23):5556.
  • Pharmaceuticals (Basel).2024, 17(9):1130.
  • Virol J.2024, 21(1):95.
  • Anesth Pain Med (Seoul).2020, 15(4):478-485.
  • Molecules.2019, 24(20):3755
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • Oxid Med Cell Longev2019, 9056845:13
  • Isogambogenin

    Catalog No: CFN92086
    CAS No: 173938-23-3
    Price: Inquiry(manager@chemfaces.com)
    Desoxygambogenin

    Catalog No: CFN92088
    CAS No: 173614-93-2
    Price: $318/10mg
    Isogambogenic acid

    Catalog No: CFN92096
    CAS No: 887923-47-9
    Price: $318 /5mg
    Gambogenic acid

    Catalog No: CFN92097
    CAS No: 173932-75-7
    Price: $218/20mg
    10-Methoxygambogenic acid

    Catalog No: CFN95450
    CAS No: 2095102-72-8
    Price: $318/10mg
    Gambogic acid

    Catalog No: CFN90172
    CAS No: 2752-65-0
    Price: $30/20mg
    Neogambogic acid

    Catalog No: CFN90175
    CAS No: 93772-31-7
    Price: $258/20mg
    Isogambogic acid

    Catalog No: CFN95440
    CAS No: 149655-52-7
    Price: $318/10mg
    Gambogin

    Catalog No: CFN92089
    CAS No: 173792-67-1
    Price: Inquiry(manager@chemfaces.com)
    Epigambogic acid

    Catalog No: CFN92098
    CAS No: 887606-04-4
    Price: $338/10mg
    Acta Biochim Biophys Sin (Shanghai). 2011 Sep;43(9):698-702.
    The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells.[Pubmed: 21785112]
    Neogambogic acid (NGA), an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect. We hypothesize that NGA may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.
    METHODS AND RESULTS:
    To investigate its anticancer mechanism in vitro, MCF-7 cells were treated with various concentrations of NGA. Results of MTT (methyl thiazolyl tetrazolum) assay showed that treatment with NGA significantly reduced the proliferation of MCF-7 cells in a dose-dependent manner. NGA could increase the expression of the apoptosis-related proteins FasL, caspase-3, caspase-8, caspase-9, and Bax and decrease the expression of anti-apoptotic protein Bcl-2 accompanied by the mitochondrial transmembrane damage. The antiproliferative effect of NGA on MCF-7 cells is due to the G(0)/G(1) arrest, increased apoptosis and activation of Fas/FasL and cytochrome C pathway.
    CONCLUSIONS:
    These results provide an important insight into the cellular and molecular mechanisms through which NGA impairs the proliferation of breast cancer cells.
    Glucoliquiritin

    Catalog No: CFN95011
    CAS No: 93446-18-5
    Price: $318/10mg
    Verbasoside

    Catalog No: CFN95015
    CAS No: 61548-34-3
    Price: $318/5mg
    Dactylorhin A

    Catalog No: CFN95032
    CAS No: 256459-34-4
    Price: $238/20mg
    Henricine

    Catalog No: CFN95244
    CAS No: 107783-46-0
    Price: $413/5mg
    Isosilychristin

    Catalog No: CFN95369
    CAS No: 77182-66-2
    Price: $318/5mg
    Maingayone

    Catalog No: CFN95479
    CAS No: 271585-66-1
    Price: $318/10mg
    Ganoderic acid GS-2

    Catalog No: CFN95549
    CAS No: 1206781-65-8
    Price: $413/5mg
    Calleryanin

    Catalog No: CFN95556
    CAS No: 20300-53-2
    Price: $318/5mg
    3',3'''-Binaringenin

    Catalog No: CFN95558
    CAS No: 145399-99-1
    Price: $413/5mg
    N-Demethylfordianoside

    Catalog No: CFN95589
    CAS No: N/A
    Price: $318/10mg