Murralongin
Murralongin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Institut Pasteur Korea2020, doi: 10.21203.
Chulalongkorn University2024, ssrn.4716057.
Environ Toxicol.2021, doi: 10.1002
J Appl Biol Chem2023, 66:455−461
BMC Complement Med Ther. 2020, 20(1):94.
Eur J Pharmacol.2024, 975:176644.
J Traditional Thai Medical Res.2022, 8(1):pp1-14.
Molecules.2021, 26(23):7390.
Front Pharmacol.2023, 14:1095083.
Biofactors.2018, 44(2):168-179
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J Nat Prod. 2010 May 28;73(5):1012-4.
Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis.[Pubmed:
20423106 ]
METHODS AND RESULTS:
Two new coumarin compounds (1 and 2), phebalosin (3), its derived artifact Murralongin (4), and murrangatin acetonide (5) were isolated from the leaves of Galipea panamensis. The structures of 1 and 2 were assigned as 7-{[(2R*)-3,3-dimethyloxiran-2-yl]methoxy}-8-[(2R*,3R*)-3-isopropenyloxiran-2-yl]-2H-chromen-2-one and 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, respectively, on the basis of their spectroscopic data (primarily NMR and MS). Compounds 1-3 were tested against axenic amastigote forms of Leishmania panamensis and displayed 50% effective concentrations (EC(50)) of 9.9, 10.5, and 14.1 microg/mL, respectively.
CONCLUSIONS:
These three compounds also displayed cytotoxicity (IC(50)) at concentrations of 9.7, 33.0, and 20.7 microg/mL, respectively, on human promonocytic U-937 cells.
Arch Pharm Res. 2011 Apr;34(4):527-31.
C-7 oxygenated coumarins from the fruits of Micromelum minutum.[Pubmed:
21544717]
METHODS AND RESULTS:
A new 7-oxygenated coumarin, 7-demethylMurralonginol isovalerate (1), and a new natural product, Murralonginol (2), together with seven known 7-oxygenated coumarins, Murralonginol isovalerate (3), Murralongin (4), micromelin (5), scopoletin (6), microminutin (7), murrangatin (8), and minumicrolin (9), were isolated from the fruits of Micromelum minutum. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data.
CONCLUSIONS:
Among these isolates, compounds 2 and 4 - 9 exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100.
