Isomurralonginol acetate
Standard reference
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Tetrahedron.1991 Dec2;47(47):9737–9742.
Total syntheses of microminutin and other coumarins through the key intermediate isomurralonginol.[Reference:
WebLink]
METHODS AND RESULTS:
A straightforward route to isomurralonginol (1) from umbelliferone (4 steps, 59% yield) is described. Isomurralonginol is used as the key intermediate in the preparation of Isomurralonginol acetate (2) (1 step, 94% yield), murralongin (3) (1 step, 75% yield) and microminutin (2 steps and 38% yield).
CONCLUSIONS:
The synthesis of microminutin involves the selenolactonization of α, β-substituted vinyl acetic acid (12) (50% yield) with spontaneous elimination of the selenyl moiety, without oxidation, to the unsaturated lactone.
