Mulberrofuran A
Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Sci Rep.2019, 9:12132
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Evid Based Complement Alternat Med.2021, 2021:5319584.
Phytother Res.2022, 10.1002:ptr.7626.
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ACS Omega.2023, 8(36):32424-32431.
Biomed Pharmacother.2024, 179:117365.
Molecules.2019, 24(11):E2044
Food Chem.2024, 452:139555.
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Chem. Pharm. Bull., 1986, 34(3):1223-7
Effects of flavonoids and related compounds from mulberry tree on arachidonate metabolism in rat platelet homogenates[Pubmed:
3089631]
The effects of various flavonoids and related compounds isolated from the root bark of mulberry tree on rat platelet lipoxygenase and cyclooxygenase products formed from [1-14C] arachidonic acid were studied.
METHODS AND RESULTS:
Morusin was found to inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products) more strongly than the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product). Oxydihydromorusin and kuwanon C were also found to inhibit the formation of thromboxane B2 more strongly than the formations of HHT and 12-HETE.
CONCLUSIONS:
Mulberrofuran A inhibited the formations of HHT and thromboxane B2, but it increased the formation of 12-HETE. Albanol B and mulberrofuran F did not affect arachidonate metabolism in rat platelet homogenates.arachidonate metabolism in rat platelet homogenates.
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