Miltipolone
Miltipolone is a good and broad-spectrum inhibitor against the growth of cancer cells. It also possibly acts as a Fe(2+) chelator to conduct its inhibitory activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Eur J Med Chem. 2011 Apr;46(4):1117-21.
Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells.[Pubmed:
21296467 ]
Miltipolone (1) was discovered as a good and broad-spectrum inhibitor against the growth of cancer cells from "Danshen" based on the activity-driven screening of TCMs.
METHODS AND RESULTS:
The structural features make 1 easily tautomerize between different forms and 1 is linked and stabilized by intermolecular O-H⋯O hydrogen bonds in the crystal structure. The interaction of 1 in ddH(2)O solution with Co(2+), Mn(2+), Zn(2+), Fe(2+) or Fe(3+) changed UV absorption values; the chelation of 1 with Fe(2+) or Fe(3+) also altered the characteristic UV absorption peaks. However, only did Fe(2+) reverse 1's inhibition against the growth of cancer cells;
METHODS AND RESULTS:
therefore, we concluded that 1 possibly acts as a Fe(2+) chelator to conduct its inhibitory activity.
