Menisporphine
Menisporphine shows cytotoxic activity on the target cancer cell lines. It also shows significant angiogenesis inhibitions.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Mol Biol Rep.2023, 50(5):4029-4038.
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Inflammation.2022, 45(6):2529-2543.
Sci Rep.2015, 5:13194
Molecules.2015, 20(10):19172-88
Int J Mol Sci.2020, 21(8):2790.
J Ethnopharmacol.2019, 228:132-141
Int J Mol Sci.2023, 24(24):17589.
Front Pharmacol.2023, 14:1095083.
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Planta Med. 2012 Nov;78(17):1873-7.
New alkaloids and cytotoxic principles from Sinomenium acutum.[Pubmed:
23059629 ]
METHODS AND RESULTS:
Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines.
CONCLUSIONS:
Dauriporphine (16), 6-O-demethylMenisporphine (17), bianfugecine (18), Menisporphine (19), and 6-O-demethyldauriporphine (20) showed differential effects in their cytotoxic activity on the target cancer cell lines. Significant angiogenesis inhibitions of 16 and 19 were also observed.
Arch Pharm Res. 2006 Aug;29(8):627-32.
Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes of Sinomenium acutum.[Pubmed:
16964757]
METHODS AND RESULTS:
Chromatographic separation of the MeOH extract from the stems and rhizomes of Sinomemium acutum led to the isolation of nine alkaloids and a lignan. Their structures were determined to be dauriporphine (1), bianfugecine (2), dauriporphinoline (3), Menisporphine (4), (-)-syringaresinol (5), N-feruloyltyramine (6), acutumine (7), dauricumine (8), sinomenine (9), and magnoflorine (10) by spectroscopic means. These compounds were examined for their P-gp mediated MDR reversal activity in human cancer cells.
CONCLUSIONS:
Compound 1 showed the most potent P-gp MDR inhibition activity with an ED50 value 0.03 microg/mL and 0.00010 microg/mL in the MES-SA/DX5 and HCT15 cells, respectively.
