Podophyllotoxinone
Podophyllotoxinone shows inhibitory activity against L1210 leukemia and KB cells in vitro.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Biol Pharm Bull.2017, 40(6):797-806
Acta Physiologiae Plantarum2016, 38:7
J Appl Biol Chem2021, 64(3):245-251.
Neuropharmacology2019, 151437
Academic J of Second Military Medical University2018, 39(11)
Biochem Pharmacol.2017, 130:10-20
Nutr Metab (Lond).2019, 16:31
ACS Pharmacol Transl Sci.2024, 7(2):395-405.
Molecules.2019, 24(16):E2985
Sustainable Chemistry & Pharmacy2022, 30:100883.
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Chinese Journal of Pharmaceuticals, 1993.
SYNTHESIS AND ANTITUMOR ACTIVITY OF PODOPHYLLOTOXINONE AND ITS HYDROXYIMINO ANALOGUES[Reference:
WebLink]
METHODS AND RESULTS:
Podophyllotoxinone and its hydroxyimino analogues have been synthesized by oxidation and oximation.
CONCLUSIONS:
The results of their inhibitory activities against L1210 leukemia and KB cells in vitro indicated that they were generally weaker than that of etoposide.
