Koumine N-oxide
Koumine N-oxide is a natural product from Gelsemium elegans.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
The Journal of Korean Medicine2022, 43(3): 79-93.
Molecules.2023, 28(10):4121.
Pharmaceuticals (Basel).2024, 17(6):727.
Academic J of Second Military Medical University2019, 40(1)
Phytochem Anal.2022, doi: 10.1002
J Pharmacol Sci.2021, 147(2):184-191.
Metabolites2023, 13(1), 3.
Separations2021, 8(1), 1.
Oxid Med Cell Longev.2022, 2022:5888636.
J Agric Food Chem.2024, acs.jafc.4c01387.
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Tetrahedron, 1988 , 44 (16) :5075-5094.
Studies on the indole alkaloids of gelsem1um elegans (thailand): structure elucidation and proposal of biogenetic route[Reference:
WebLink]
METHODS AND RESULTS:
Chemical investigation of the roots of collected in Thailand resulted in the isolation of the new indole alkaloids, 16-epi-voacarpine, 19-hydroxydihydrogelsevirine, and 19-(Z)-taberpsychine, along with eight known bases.
CONCLUSIONS:
Among them, the structure of “akuammidine” and koumidine were revised to have 19-(Z) ethylidene configuration. From the seeds of 14-hydroxygelsedine was obtained. Furthermore, three new alkaloids, Koumine N-oxide, gelsemine N-oxide, and 19-oxo-gelsenicine, were found from the leaves of . A new and plausible biogenetic route of gelsemium alkaloids is proposed.
