Ipecoside

Ipecoside
Product Name Ipecoside
CAS No.: 15401-60-2
Catalog No.: CFN93116
Molecular Formula: C27H35NO12
Molecular Weight: 565.57 g/mol
Purity: >=98%
Type of Compound: Iridoids
Physical Desc.: Powder
Source: The herbs of Psychotria ipecacuanha
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Reference standards.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • QASCF2022, 14(4).
  • Huazhong Agricultural University2022, pp34.
  • Biosci Rep.2020, 40(8):BSR20201219.
  • Viruses.2017, 9(10)
  • Curr Issues Mol Biol.2022, 44(5):2300-2308.
  • Int J Mol Sci.2023, 24(8):7442.
  • Food Chem.2021, 377:131976.
  • J Cell Mol Med.2023, jcmm.17968.
  • Oncotarget.2017, 8(64):108006-108019
  • Food Res Int.2020, 133:109130.
  • Liquiritin

    Catalog No: CFN99154
    CAS No: 551-15-5
    Price: $40/20mg
    Luteolin-7-O-glucuronide

    Catalog No: CFN98512
    CAS No: 29741-10-4
    Price: $118/20mg
    Genistein

    Catalog No: CFN98681
    CAS No: 446-72-0
    Price: $30/20mg
    Aloin A

    Catalog No: CFN99943
    CAS No: 1415-73-2
    Price: $30/20mg
    gamma-Mangostin

    Catalog No: CFN98396
    CAS No: 31271-07-5
    Price: $70/20mg
    J Biol Chem. 2008 Dec 12;283(50):34650-9.
    The new beta-D-glucosidase in terpenoid-isoquinoline alkaloid biosynthesis in Psychotria ipecacuanha.[Pubmed: 18927081]
    Ipecac alkaloids produced in the medicinal plant Psychotria ipecacuanha such as emetine and cephaeline possess a monoterpenoid-tetrahydroisoquinoline skeleton, which is formed by condensation of dopamine and secologanin. Deglucosylation of one of the condensed products N-deacetylisoIpecoside (1 alpha(S)-epimer) is considered to be a part of the reactions for emetine biosynthesis, whereas its 1 beta(R)-epimer N-deacetylIpecoside is converted to Ipecoside in P. ipecacuanha.
    METHODS AND RESULTS:
    Here, we isolated a cDNA clone Ipeglu1 encoding Ipecac alkaloid beta-D-glucosidase from P. ipecacuanha. The deduced protein showed 54 and 48% identities to raucaffricine beta-glucosidase and strictosidine beta-glucosidase, respectively. Recombinant IpeGlu1 enzyme preferentially hydrolyzed glucosidic Ipecac alkaloids except for their lactams, but showed poor or no activity toward other substrates, including terpenoid-indole alkaloid glucosides. Liquid chromatography-tandem mass spectrometry analysis of deglucosylated products of N-deacetylisoIpecoside revealed spontaneous transitions of the highly reactive aglycons, one of which was supposed to be the intermediate for emetine biosynthesis. IpeGlu1 activity was extremely poor toward 7-O-methyl and 6,7-O,O-dimethyl derivatives. However, 6-O-methyl derivatives were hydrolyzed as efficiently as non-methylated substrates, suggesting the possibility of 6-O-methylation prior to deglucosylation by IpeGlu1. In contrast to the strictosidine beta-glucosidase that stereospecifically hydrolyzes 3 alpha(S)-epimer in terpenoid-indole alkaloid biosynthesis, IpeGlu1 lacked stereospecificity for its substrates where 1 beta(R)-epimers were preferred to 1 alpha(S)-epimers, although Ipecoside (1 beta(R)) is a major alkaloidal glucoside in P. ipecacuanha, suggesting the compartmentalization of IpeGlu1 from Ipecoside.
    CONCLUSIONS:
    These facts have significant implications for distinct physiological roles of 1 alpha(S)- and 1 beta(R)-epimers and for the involvement of IpeGlu1 in the metabolic fate of both of them.
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Momordicoside X

    Catalog No: CFN95170
    CAS No: 1333321-50-8
    Price: $368/5mg
    1,2-Epoxy-10(14)-furanogermacren-6-one

    Catalog No: CFN95214
    CAS No: 383368-24-9
    Price: $318/10mg
    (-)-Cadin-4,10(15)-dien-11-oic acid

    Catalog No: CFN95246
    CAS No: 1124353-23-6
    Price: $318/5mg
    Vicinin 2

    Catalog No: CFN95249
    CAS No: 90456-53-4
    Price: $368/5mg
    Oleracein E

    Catalog No: CFN95441
    CAS No: 1021950-79-7
    Price: $318/5mg
    Cagayanin

    Catalog No: CFN95480
    CAS No: 99096-51-2
    Price: $318/20mg
    (3,4-Dihydroxyphenyl)methyl 3-(beta-D-glucopyranosyloxy)-4-hydroxybenzoate

    Catalog No: CFN95531
    CAS No: 877461-90-0
    Price: $318/10mg
    Mahuannin G

    Catalog No: CFN95553
    CAS No: N/A
    Price: $318/5mg
    4-Keto-laurifoline

    Catalog No: CFN95594
    CAS No: N/A
    Price: $318/10mg