Interiotherin A
Interiotherin A inhibits HIV replication with the EC50 value of 3.1 micrograms/mL.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Chung Shan Medical University2020, US20200323790A1
BMC Plant Biol.2022, 22(1):128.
Phytother Res.2023, 37(10):4587-4606.
Anal Bioanal Chem.2018, 410(5):1561-1569
Int J Biol Macromol.2019, 126:653-661
Nutrients2022, 14(3),695.
Pharmaceutics.2023, 15(6):1771.
J Biochem Mol Toxicol.2020, 34(7):e22489.
Eur J Pharmacol.2020, 889:173589.
Antioxidants (Basel).2020, 9(6):526.
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J Nat Prod. 1996 Nov;59(11):1066-8.
Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.[Pubmed:
8946749 ]
METHODS AND RESULTS:
Two new lignans, Interiotherin A (1) and interiotherin B (2), along with two known lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and stereochemistries were determined from spectral data.
CONCLUSIONS:
Compounds 1 and 4 inhibit HIV replication with EC50 values of 3.1 and 0.5 micrograms/mL, respectively.
Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1597-601.
Chemical constituents of petroleum ether extract of fruits of Schisandra sphenanthera.[Pubmed:
22993989]
To study the chemical constituents in the fruits of Schisandra sphenanthera.
METHODS AND RESULTS:
The constituents were isolated by their silica gel column, Sephadex LH-20 gel column, and their structures were elucidated by their chemical properties and spectroscopic analyses. Twelve compounds were isolated and identified as (+)-anwulignan (1), deoxyschizandrin (2), Interiotherin A (3), schisantherin A (4), beta-sitosterol (5), schisantherin D (6), 4-hydroxybenzaldehyde (7), 6-O-benzoylgomisin O (8), schizandronic acid (9), schisanlactone D (10), schisanlactone B (11), kadsulactone A (12).
CONCLUSIONS:
Compounds 3, 7, 10-12 were obtained from this plant for the first time.
