Ilexoside D
Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Tetrahedron Letters, 1991, 32(29):3535-3538.
Ilexosides A, B, C and D, anti-allergic 18,19-seco-ursane glycosides from fruit of Ilex crenata.[Reference:
WebLink]
METHODS AND RESULTS:
Four novel 18,19-seco-ursane glycosides named ilexoside A, ilexoside B, ilexoside C and Ilexoside D have been isolated from Ilex crenata Thunb.. Their structures were established as novel glycosides of 3β-hydroxy-19-oxo-18,19-seco-11,13(18)-ursadiene-28-oic-acid on the basis of chemical and spectroscopic analysis.
CONCLUSIONS:
They exhibited ant-allergic activities.The ant-alergic effect of Ilexoside A(1) ,ilexoside B(2) ,ilexoside C(3) and Ilexoside D(4) are 10 times as potent as glycyrrhizin.
Archives of Pharmacal Research, 1993, 16(3):209-212.
Anticoagulant activity of ilexoside D, a triterpenoid saponin fromIlex pubescens.[Reference:
WebLink]
The anti-coagulant activity of Ilexoside D isolated from the roots ofIlex pubescens Hook. et Arn. was investigated inin vivo andin vitro models of blood coagulation in rats.
METHODS AND RESULTS:
On oral administration, Ilexoside D prolonged the bleeding time and the whole blood recalcified clotting time, but not the plasma recalcified clotting time.In vitro, Ilexoside D did not affect the recalcified clotting times of whole blood, platelet-rich plasma (PRP), and platelet-poor plasma (PPP) while in the presence of tissue factor the compound prolonged the reduced prothrombin times of whole blood, PRP and PPP in the dose-dependent manner.
CONCLUSIONS:
These results indicate that Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity.
