Guggulsterone E&Z
Guggulsterone E&Z is a natural product from Ailanthus grandis, it did not show antimicrobial activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Int.J.Curr.Microbiol.App.Sci.,2016,5(10):20-6.
Antimicrobial Activity of Guggulsterone E and Z[Reference:
WebLink]
Guggulsterone is a main active compound of gum guggul, which has commonly used as ant-inflammatory, hepatoprotective, muscle relaxing, anti-arthritic, hypolipidemic, hypocholestrolemic and anti-obesity.
METHODS AND RESULTS:
In the present study, its antimicrobial activity of Guggulsterone E&Z against five microorganisms i.e. Escherichia coli (Wild), E. Cole (DH5α), Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis were undertaken. Disc diffusion method was used for antimicrobial activity assessment of compound Guggulsterone E&Z .
The discs were impregnated with 100 and 200 μg per disc and exposed to culture bed of five test organism i.e. E. coli (Wild), E. coli (DH5α), M. luteus, S. aureus and B. subtilis.
CONCLUSIONS:
After 24 hours of incubation at 37 °C, it was observed that the Guggulsterone E&Z did not show any inhibition zone against the all five test organisms.
Pharmacognosy Journal, 2013 , 5 (6) :259-264.
Development of HPTLC method for estimation of piperine, guggulsterone E and Z in polyherbal formulation[Reference:
WebLink]
The different batches of formulation were prepared in laboratory by using authenticated raw material and were subjected to various physical and chemical evaluations. Then the prepared formulation and three commercial formulations were investigated for the qualitative and quantitative estimation of mentioned constituents.
METHODS AND RESULTS:
The methanolic extract of all formulations were quantified by using HPTLC studies. Linear regression data for the calibration curves of standards viz. piperine, guggulsterone E and Z showed a good linear relationship over a concentration range of 0.06–0.14 μg/spot, 2.5–17.5 μg/spot, 5–30 μg/spot respectively with the correlation coefficient of 0.99085, 0.99847, 0.9990 respectively and thus exhibits good linearity between concentration and area. The content of guggulsterone E (14.68 %w/w, 13.05 %w/w, 6.36 %w/w, 14.36 %w/w); guggulsterone Z (31.81 %w/w, 26.95 %w/w, 11.62 %w/w, 23.86 %w/w); and piperine (0.068 %w/w, 0.0150 %w/w, 0.321 %w/w, 0.0375 %w/w) were found in TF, TN, TM, TP prepared and three marketed formulation respectively.
CONCLUSIONS:
The proposed HPTLC method was found to be rapid, simple and linear for quantitative estimation of piperine, Guggulsterone E&Z in different formulations and extracts.
