Glycinol

Regen Med. 2017 Jul;12(5):513-524.

Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells.[Pubmed: 28718749 ]

Phytoestrogens, such as Glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential.
METHODS AND RESULTS:
The osteogenic effects of Glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and Glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following Glycinol treatment. ER antagonist studies further support that Glycinol promotes osteogenesis through ER signaling.
CONCLUSIONS:
The results from these studies support investigating Glycinol as a potential preventive or treatment for osteoporosis.

Eksp Klin Farmakol. 2010 Oct;73(10):21-4.

[Influence of new neurohypophyseal hormone analogs on sodium and water reabsorption in rat kidney].[Pubmed: 21254509]

New analogs of some neurohypophyseal hormones (oxypressin, hydrin, glumitocin, vasotocin) have been synthesized.
METHODS AND RESULTS:
Experiments with injection of these peptides to rats showed that substitution of C-terminal glycinamide on beta-ethanolamine (Glycinol) or ethylamine in 1-deamino-arginine vasotocin resulted in loss of natriuretic but not antidiuretic activity.
CONCLUSIONS:
Analogs of oxypressin and hydrin exhibited neither natriuretic activity nor ability to affect water reabsorption. Glumitocin analog induced renal sodium ion excretion and did not influence potassium ion excretion.