Glochidone
Glochidone shows pronounced antinociceptive properties in mice.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Int J Mol Sci.2024, 25(17):9730.
Processes2021, 9(11),2065.
J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):1-20.
J. of Agricultural Science2015, 1916-9760
Appl. Sci.2021, 11(19),9343.
Industrial Crops and Products2022, 186:115298
Chem Biol Interact.2016, 260:168-175
Cell Death Differ.2021, 1-8.
Sci Rep.2023, 13(1):14594.
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Revista Brasileira De Farmacognosia, 2012,22 (3) :682-713.
Review of the genus Ipomoea: traditional uses, chemistry and biological activities[Reference:
WebLink]
METHODS AND RESULTS:
Study in mice indicated that both methanolic extract and two fractions (ethyl acetate and aqueous) exhibited antinociceptive activity against two classical models of pain, neurogenic and inflammatory. This study justifies at least in part, the traditional use of this plant to treat dolorous process (Souza et al., 2000).
CONCLUSIONS:
Some constituents isolated from I. pes-caprae, such as, quercetin 3-O-β-D-glucofuranoside (55), β-amyrin acetate (104) α-amyrin acetate (105), betulinic acid (107) and Glochidone (108) showed pronounced antinociceptive properties in mice.
Australian Journal of Chemistry.1974;27(12):2711 - 2714.
Terpenoid constituents of Indian Glochidion species: Glochidion accuminatum and Glochidion thomsoni. Partial synthesis of glochidone.[Reference:
WebLink]
METHODS AND RESULTS:
Glochidone (1), glochidonol(2) and β-sitosterol were isolated from Glochidion accuminatum while G. thomsoni furnished Glochidone (1), lup- 20(29)-ene-1β,3β-diol (3) and β-sitosterol. A partial synthesis of Glochidone has been achieved in 25% yield by the 2,3-dichloro-5,6- dicyanobenzoquinone dehydrogenation of lupenone.
