Ganoderic acid S

Ganoderic acid S
Product Name Ganoderic acid S
CAS No.: 104759-35-5
Catalog No.: CFN99066
Molecular Formula: C30H44O3
Molecular Weight: 452.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The fruit body of Ganoderma lucidum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $568/5mg
A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon cancer, hepatic cancer, breast cancer, lung cancer or leukemia. Ganoderic acid S and Mf induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Journal of Plant Growth Regulation2022, 10705-2.
  • J Holistic Integrative Pharm.2023, 4(1):14-28
  • International Food Research Journal2018, 25(6):2560-2571
  • Heliyon.2022, e12337.
  • Food Funct.2024, 15(8):4262-4275.
  • Oxid Med Cell Longev2020, 12
  • Phytomedicine.2023, 116:154841.
  • Phytomedicine.2018, 40:37-47
  • Chem Biol Interact.2020, 328:109200.
  • Russian Journal of Bioorganic Chemistry2023, 49:1689¨C1698.
  • Ganoderic acid DM

    Catalog No: CFN99815
    CAS No: 173075-45-1
    Price: $318/5mg
    11-Keto-ganoderic acid DM

    Catalog No: CFN95593
    CAS No: N/A
    Price: $413/5mg
    Ganoderiol D

    Catalog No: CFN95568
    CAS No: 114567-45-2
    Price: $413/5mg
    Lucidumol A

    Catalog No: CFN95059
    CAS No: 217476-73-8
    Price: $318/5mg
    23S-hydroxy-11,15-dioxo-ganoderic acid DM

    Catalog No: CFN80433
    CAS No: 1085273-49-9
    Price: Inquiry(manager@chemfaces.com)
    New compound 19

    Catalog No: CFN95538
    CAS No: N/A
    Price: $413/5mg
    Ganoderic acid GS-3

    Catalog No: CFN95518
    CAS No: 1206781-66-9
    Price: $413/5mg
    Resinacein D

    Catalog No: CFN95591
    CAS No: 2231061-47-3
    Price: $413/5mg
    11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid

    Catalog No: CFN95592
    CAS No: 1245703-70-1
    Price: $413/5mg
    Ganolucidic acid E

    Catalog No: CFN95536
    CAS No: 114567-50-9
    Price: $318/5mg
    US20140294753[P]. 2014.
    Therapeutic Composition for Treating Cancers.[Reference: WebLink]
    Disclosed herein is a composition that includes a novel combination of triterpenoids for the treatment or prophylaxis of a cancer. The triterpenoids includes at least Ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS). The composition is suitable for the treatment or prophylaxis of colon cancer, hepatic cancer, breast cancer, lung cancer or leukemia.
    Phytomedicine. 2011 Mar 15;18(5):349-55.
    Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells.[Pubmed: 21036023 ]

    METHODS AND RESULTS:
    In this work, the effects of a pair of positional isomer of ganoderic acids (GAs), namely ganoderic acid Mf (GA-Mf) and Ganoderic acid S (GA-S) purified from the fermented mycelia of Ganoderma lucidum, on induction of cell apoptosis and the apoptotic pathway in HeLa cells were investigated. The results demonstrate that both isomers decreased cell population growth on various human carcinoma cell lines by MTT assay, while GA-Mf had better selectivity between normal and cancer cells. The flow cytometry analysis indicated that treatment of HeLa cells with GA-S caused cell cycle arrest in the S phase, while GA-Mf caused cell cycle arrest in the G1 phase. Compared with GA-S, GA-Mf had more potent increase in the number of early and late apoptotic cells. Treatment of HeLa cells with each isomer decreased the mitochondria membrane potential and caused the release of cytochrome c from mitochondria into the cytosol. In addition, stimulation of caspase-3 and caspase-9 activity was observed. The Bax/Bcl-2 ratio was also increased in GA-treated HeLa cells. The results demonstrated that both isomers GA-Mf and GA-S induced apoptosis of human HeLa cells through a mitochondria mediated pathway, but they had the different cell cycle arrest specificity.
    CONCLUSIONS:
    The findings will be helpful to the development of useful cancer chemopreventive compounds from G. lucidum.
    Lucidenic acid D2

    Catalog No: CFN95020
    CAS No: 98665-16-8
    Price: $268/5mg
    Orientalide

    Catalog No: CFN95136
    CAS No: 72704-05-3
    Price: $368/5mg
    (E)-6-O-(p-coumaroyl)scandoside methyl ester

    Catalog No: CFN95192
    CAS No: 83946-90-1
    Price: $218/10mg
    Sphenanlignan

    Catalog No: CFN95245
    CAS No: 866347-36-6
    Price: $318/5mg
    Acacetin 7-[rhamnosyl-(1->2)-galacturonide]

    Catalog No: CFN95358
    CAS No: 38722-95-1
    Price: $318/10mg
    Ternatumoside II

    Catalog No: CFN95366
    CAS No: 1473419-87-2
    Price: $318/5mg
    Cajanine

    Catalog No: CFN95448
    CAS No: 87402-84-4
    Price: $318/5mg
    Isorhamnetin 3,5-O-diglucoside

    Catalog No: CFN95488
    CAS No: 2035413-03-5
    Price: $318/10mg
    Ganoderic acid J

    Catalog No: CFN95516
    CAS No: 100440-26-4
    Price: $318/10mg
    Apigenin-6-C-beta-D-glucopyranosyl-8-C-[alpha-L-rhamnopyranosyl-(1->2)]-beta-glucopyranoside

    Catalog No: CFN95540
    CAS No: 1646598-06-2
    Price: $368/5mg