Dihydroseselin
Dihydroseselin type of pyranocoumarin possessing a 4'-isovaleryl group is important to suksdorfin's enhanced anti-HIV activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Neurotoxicology.2022, 91:218-227.
Korean Journal of Pharmacognosy.2020, 51(2):100-106
Medicinal Chemistry Research 2021, 30:1117-1124.
Vietnam Journal of Science2022, 64(2), 69-75.
Int J Mol Sci.2020, 21(9):3144.
Environ Toxicol.2020, doi: 10.1002
Drug Des Devel Ther.2020, 14:61-71
Pharm Biol.2021, 59(1):134-145.
Theranostics.2023, 13(9):3103-3116.
Preprints2022, 202211.0388.v1.
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Journal of Mathematical Analysis & Applications, 2002, 275(1):386-401.
Eccentric distance sum: A novel graph invariant for predicting biological and physical properties.[Reference:
WebLink]
Eccentric distance sum—a novel graph invariant with vast potential in structure activity/property relationships has been conceptualized in the present study.
This graph invariant displayed high discriminating power with respect to both biological activity and physical properties.
METHODS AND RESULTS:
The structure activity relationship of eccentric distance sum was investigated with regard to anti-HIV activity of Dihydroseselins. The values of eccentric distance sum of each analogue in the data set were computed and active range identified. Subsequently, biological activity was assigned to each analogue in the data set, which was then compared with the reported anti-HIV activity of Dihydroseselin analogues. Surprisingly the accuracy of prediction was found to be more than 88% with regard to anti-HIV activity. On the other hand, investigations pertaining to quantitative structure property relationship of the novel graph invariant with regard to various physical properties of diverse nature, for data sets consisting of primary amines, secondary amines and alcohols revealed correlation percentages ranging from 93% to 99%.
CONCLUSIONS:
The over all results with regard to structure–activity and quantitative structure–property studies using eccentric distance sum were better than the corresponding values obtained using Wiener's index.
