Cymarin
Cymarin exhibits potent cytotoxicity against a human solid tumor cell line A549 (human lung carcinoma), while being inactive on murine leukemic cells (L1210).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Int J Mol Sci.2024, 25(2):764.
Biomol Ther (Seoul).2020, 28(6):542-548.
Int Immunopharmacol.2021, 100:108073.
Biomolecules.2021, 11(10):1537.
Nat Commun.2023, 14(1):5075.
Microchemical Journal2023, 194:109249
Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
Invest New Drugs.2017, 35(2):166-179
J Microbiol Biotechnol.2022, 32(2):141-148.
Biomolecules2021, 11(10),1513.
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Phytotherapy Researth,2003, 17(5):568-570.
Inhibitory effect of Adonis amurensis components on tube‐like formation of human umbilical venous cells.[Reference:
WebLink]
METHODS AND RESULTS:
Antiangiogenic activity‐guided fractionation and isolation carried out on the methanol extract of Adonis amurensis led to the identification of three compounds, namely Cymarin, cymarol, and cymarilic acid. Amongst the three compounds, cymarilic acid was isolated from this plant for the first time. This compound showed no significant cytotoxicity against tumor cell lines but was found to be strongly inhibitory toward tube formation induced by human umbilical venous endothelial (HUVE) cells.
CONCLUSIONS:
Cymarin and cymarol exhibited potent cytotoxicity against a human solid tumor cell line A549 (human lung carcinoma), while being inactive on murine leukemic cells (L1210).
Journal of Pharmacy & Pharmacology, 1961, 13(1):279-282.
The isolation of cymarin and periplocymarin from the seeds of Castilloa elastica Cerv.[Reference:
WebLink]
METHODS AND RESULTS:
Two known cardiac glycosides, Cymarin and periploCymarin have been isolated from the seeds of the South American rubber tree, Castilloa elastica.
