Curcolonol

J Nat Prod. 1998 Dec;61(12):1531-4.

Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria.[Pubmed: 9868158]

METHODS AND RESULTS:
Bioassay-directed fractionation of an EtOH extract of Curcuma zedoaria led to isolation of an active curcuminoid, which was identified as demethoxycurcumin (2) by comparison of its 1H and 13C NMR spectra with literature data and by direct comparison with synthetic material. Curcumin (1) and bisdemethoxycurcumin (3) were also obtained. Curcuminoids (1-3) were synthesized and demonstrated to be cytotoxic against human ovarian cancer OVCAR-3 cells.
CONCLUSIONS:
The observed CD50 values of 1, 2, and 3 were 4.4, 3.8, and 3.1 microg/mL, respectively. Three additional novel compounds, 3, 7-dimethylindan-5-carboxylic acid (4), Curcolonol (5), and guaidiol (6), were also isolated from the EtOH extract. The structures and relative stereochemistry of 4-6 were determined by spectroscopic methods and X-ray crystallographic analysis.

Yao Xue Xue Bao. 2005 Jun;40(6):525-8.

Studies on the chemical constituents from the roots of Chloranthus henryi.[Pubmed: 16144317]

To study the chemical constituents of the roots of Chloranthus henryi.
METHODS AND RESULTS:
The constituents of Chloranthus henryi were separated with various chromatographic techniques. structures were elucidated by physico-chemical properties and spectral data. Eight compounds were isolated from Chloranthus henryi. They were identified as Curcolonol (I), zedoarofuran (II), shizukanolide E (III) , skimmin (IV), calucanthoside (V), chloracoumarin (VI), beta-sitosterol (VII), daucosterin (VIII).
CONCLUSIONS:
Chloracoumarin (VI) is a new compound and characterized as 6,8-dimethoxy-7-O-[beta-D-apiofunanosyl(l --> 3 )-D-glucopyranosyl]-2H-benzopyran-2-one. Compounds I, II were isolated from Chloranthus henryi for the first time.