Bisdehydroneotuberostemonine
Bisdehydroneotuberostemonine shows significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 uM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production[Reference:
WebLink]
METHODS AND RESULTS:
A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), Bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation.
CONCLUSIONS:
Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 μM.
J Asian Nat Prod Res. 2002 Jun;4(2):81-5.
Alkaloids from Stemona collinsae.[Pubmed:
12067163 ]
A new alkaloid, isostenine (1), together with two known ones neotuberostemonine (2) and Bisdehydroneotuberostemonine (3) were isolated from the root of Stemona collinsae. Their structures were determined by various spectral methods.
