Apigenin 7-diglucuronide

Apigenin 7-diglucuronide
Product Name Apigenin 7-diglucuronide
CAS No.: 74696-01-8
Catalog No.: CFN91599
Molecular Formula: C27H26O17
Molecular Weight: 622.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The leaves of Turpinia arguya Seem.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Apigenin-7-diglucuronide is a flavonoid glycoside that exists in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. It protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Int J Biol Macromol.2020, 169:342-351
  • Anticancer Res.2024, 44(3):1033-1044.
  • Cancer Sci.2022, 113(4):1406-1416.
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Nutrients2020, 12(3):811.
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Phytochemistry Letters2021, 43:80-87.
  • PLoS One.2018, 13(3):e0193386
  • Front Aging Neurosci.2019, 11:230
  • Fitoterapia.2024, 175:105955.
  • Fortunellin

    Catalog No: CFN70305
    CAS No: 20633-93-6
    Price: $318/10mg
    Acacetin 7-[rhamnosyl-(1->2)-galacturonide]

    Catalog No: CFN95358
    CAS No: 38722-95-1
    Price: $318/10mg
    Neobudofficide

    Catalog No: CFN95640
    CAS No: 194602-91-0
    Price: $318/10mg
    Fortunellin-6''-beta-D-glucopyranoside (Acacetin-7-O-[2''-O-rhamnosyl-6''-O-glucosyl]-glucoside)

    Catalog No: CFN95315
    CAS No: 1218774-64-1
    Price: $318/5mg
    7,4-Di-O-methylapigenin 5-O-glucoside

    Catalog No: CFN99900
    CAS No: 197018-71-6
    Price: Inquiry(manager@chemfaces.com)
    7,4'-Di-O-methylapigenin 5-O-xylosylglucoside

    Catalog No: CFN98099
    CAS No: 221257-06-3
    Price: Inquiry(manager@chemfaces.com)
    Apigenin 5-O-neohesperidoside

    Catalog No: CFN96527
    CAS No: 850630-40-9
    Price: Inquiry(manager@chemfaces.com)
    Camellianin A

    Catalog No: CFN90992
    CAS No: 109232-77-1
    Price: $268/5mg
    Angeflorin

    Catalog No: CFN96365
    CAS No: 57498-69-8
    Price: Inquiry(manager@chemfaces.com)
    Gelomuloside B

    Catalog No: CFN96348
    CAS No: 149998-39-0
    Price: Inquiry(manager@chemfaces.com)
    Brain Res . 2017 May 15;1663:141-150.
    Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation[Pubmed: 28336272]
    Vision impairment in retinal degenerative diseases such as age-related macular degeneration is primarily associated with photoreceptor degeneration, in which oxidative stress and inflammatory responses are mechanistically involved as central players. Therapies with photoreceptor protective properties remain to be developed. Apigenin-7-diglucuronide (A7DG), a flavonoid glycoside, is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. However, the pharmacological significance of A7DG remains unknown in vivo. The current study isolated A7DG from Glechoma longituba (Nakai) Kuprian and investigated the retinal protective effect A7DG in mice characterized by bright light-induced photoreceptor degeneration. The results showed that A7DG treatment led to remarkable photoreceptor protection in bright light-exposed BALB/c mice. Moreover, A7DG treatment alleviated photoreceptor apoptosis, mitigated oxidative stress, suppressed reactive gliosis and microglial activation and attenuated the expression of proinflammatory genes in bright light-exposed retinas. The results demonstrated for the first time remarkable photoreceptor protective activities of A7DG in vivo. Inhibition of bright light-induced retinal oxidative stress and retinal inflammatory responses was associated with the retinal protection conferred by A7DG. The work here warrants further evaluation of A7DG as a pharmacological candidate for the treatment of vision-threatening retinal degenerative disorders. Moreover, given the general implication of oxidative stress and inflammation in the pathogenesis of neurodegeneration, A7DG could be further tested for the treatment of other neurodegenerative disorders.
    Gancaonin N

    Catalog No: CFN95066
    CAS No: 129145-52-4
    Price: $463/5mg
    1,3,6-Trihydroxy-2-methylanthraquinone 3-O-(6'-O-acetyl)-alpha-L-rhamnosyl-(1->2)-Beta-D-glucoside

    Catalog No: CFN95095
    CAS No: 87686-87-1
    Price: $218/10mg
    New compound 4

    Catalog No: CFN95185
    CAS No: N/A
    Price: $368/5mg
    Notoptol

    Catalog No: CFN95218
    CAS No: 88206-49-9
    Price: $318/5mg
    Platycogenin A

    Catalog No: CFN95240
    CAS No: 1459719-53-9
    Price: $388/5mg
    Henricine

    Catalog No: CFN95244
    CAS No: 107783-46-0
    Price: $413/5mg
    10-Hydroxyaloin B

    Catalog No: CFN95454
    CAS No: 134863-92-6
    Price: $318/5mg
    Ganoderiol D

    Catalog No: CFN95568
    CAS No: 114567-45-2
    Price: $413/5mg
    Methyl ganoderenate D

    Catalog No: CFN95572
    CAS No: 748136-03-0
    Price: $413/5mg
    Oxyphyllol B

    Catalog No: CFN95575
    CAS No: 226546-99-2
    Price: Inquiry(manager@chemfaces.com)