Anwuweizonic acid

J Nat Prod. 2001 Oct;64(10):1278-81.

Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.[Pubmed: 11678650]

METHODS AND RESULTS:
A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), Anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes.
CONCLUSIONS:
Moronic acid (2) showed significant anti-HIV activity (EC(50) <0.1 microg/mL, TI >186) and was modified to develop more potent anti-AIDS agents.

Japanese Journal of Pharmacognosy, 2014, 68:93-4.

Triterpenoids of Resin of Schinus terebinthifolius and Their Anti-inflammatory Effects[Reference: WebLink]

METHODS AND RESULTS:
Inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice was observed in the methanol extract of the plant resin of Schinus terebinthifolius.
CONCLUSIONS:
Five known compounds were isolated from the resin of S. terebinthifolius: betulonic acid, moronic acid, 3-oxooleanolic acid, masticadienoic acid and Anwuweizonic acid.

Pharm Biol. 2013 Sep;51(9):1204-7.

Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens.[Pubmed: 23883077]

The diethyl ether extract of the stems of Schisandra pubescens Hemsl. et Wils. (Schisandraceae) was found to exhibit cytotoxic activity in vitro. However, investigations of the bioactive constituents of this plant have been very limited. Elucidation of the cytotoxic constituents of S. pubescens was performed.
METHODS AND RESULTS:
Repeated silica gel column chromatography and preparative TLC were used for the chemical investigation of the diethyl ether extract of S. pubescens stems. All isolates were evaluated for their in vitro cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines. Nine known compounds were obtained, including four lignans, epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (-)-gomisin L₂ (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), coccinic acid (7), schisanlactone B (8) and Anwuweizonic acid (9). Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI₅₀ values of 11.83-35.65 μM.
CONCLUSIONS:
The isolation of 1-9 from S. pubescens and the cytotoxicities of 3-6 are first reported. Compounds 2-6 and 8 could be the active principles responsible for the anticancer effects of S. pubescens.