Anemosapogenin
Anemosapogenin shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chinese Journal of Hospital Pharmacy, 2003 , 23 (9) :532-3.
The anti-tumor effect of the extract from Radix Pulsatillae[Reference:
WebLink]
To extract Anemosapogenin from Radix Pulsatillae and study its anti tumor activity.
METHODS AND RESULTS:
Total saponins were isolated from Radix Pulsatillae , then hydrolyze into sapogenins , the sapogenins were purified by column chromatography. The furified substance was mixed with vegetable oil as suspension of different concentrations. Mice with transplantable tumors(HepA liver carcinoma, Ehrlich ascites cancer)were administrated continuously for ten days by i.p. with different dosages according to the mice weight. The anti tumor effect in vivo and the rate of life elongation of the mice was observed. Low concentration group and middle concentration group had obvious effect on inhibiting the growth of HepA liver carcinoma in vivo, but the high concentration group had little effect . However, the life elongation effect was not obvious.
CONCLUSIONS:
The extract from Radix Pulsatillael (3b,23 dihydroxyl 20(29) lupene 28 acid)shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.
