Agatharesinol acetonide
Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Analytical Letters.2020, doi 10.1008
Jeju National University Graduate School2023, 24478
Food Bioscience2022, 50:102187.
Biochem Biophys Res Commun.2018, 505(4):1148-1153
Pharmaceutics.2020, 12(9):845.
Foods.2023, 12(19):3647.
Molecules.2022, 27(4):1412.
Eur J Pharmacol.2022, 917:174744.
Food Chem.2019, 275:746-753
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Chem Biodivers. 2005 Apr;2(4):497-505.
Norlignans from Sequoia sempervirens.[Pubmed:
17191998]
METHODS AND RESULTS:
Six new norlignans, named sequosempervirins B-G (1-6), together with three known norlignans, agatharesinol (7), Agatharesinol acetonide (8), and sugiresinol (9), were isolated from the branches and leaves of Sequoia sempervirens. Their structures were determined mainly by high-resolution mass spectroscopy (HR-MS), and various 1D- and 2D-NMR methods, as well as, in the case of 1, by means of X-ray diffraction.
CONCLUSIONS:
Compound 8 showed anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM). The acetone extract of S. sempervirens was found to be antifungal towards Candida glabrata (IC50 = 15.98 microg/ml), and both the acetone and MeOH extracts inhibited the proteolytic activity of cathepsin B (IC50 = 4.58 and 5.49 microg/ml, resp.).
