9-O-Feruloyl-5,5'-dimethoxylariciresinol

Arch. Pharm. Res.,2014 Apr;37(4):467-72.

A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects.[Pubmed: 24014307 ]

METHODS AND RESULTS:
A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8'R)-acuminatolide (6), and (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol (9-O-Feruloyl-5,5'-dimethoxylariciresinol,7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher's esterification. The effect of compounds 1-7 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells.
CONCLUSIONS:
Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects.

Arch Pharm Res. 1999 Aug;22(4):417-22.

Two new lignans from Lindera obtusiloba blume.[Pubmed: 10489885]

METHODS AND RESULTS:
Two new furanolignans (3, 5), together with three known lignans (1, 2, 4), were isolated from the stem of Lindera obtusiloba (Lauraceae). The structures of the compounds were determined as actifolin (1), pluviatilol (2), 5,6-dihydroxymatairesinol (3), (+)-syringaresinol (4), and (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol (9-O-Feruloyl-5,5'-dimethoxylariciresinol,5) on the basis of physicochemical and spectroscopic evidences.
CONCLUSIONS:
Compounds 1, 2, 3, and 5 showed cytotoxicity against a small panel of human tumor cell lines with ED50 values of 3.40 to approximately 19.27 microg/ml.