9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid
9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.
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24 months(2-8C).
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J. Food Composition and Anal.2022, V 109:104482.
University of Stuttgart2021, 11682.
Separations2023, 10(4), 231.
Babol University of Medical Sciences2024, rs-4289336
Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
Phytochem Anal.2022, doi: 10.1002
LWT2020, 130:109535
Metabolites.2019, 9(11):E271
Biomedicines.2020, 8(11):486.
Eur J Pharm Sci.2016, 94:33-45
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J Nat Prod. 2000 Jun;63(6):817-20.
Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni.[Pubmed:
10869208]
METHODS AND RESULTS:
A novel rearranged labdane-type diterpenoid, 19(4-->3)abeo-8alpha, 13(S)-epoxylabda-4(18),14-diene (1), and two new abietane-type diterpenoids, 19-nor-abieta-4(18),8,11,13-tetraen-7-one (2) and 12-hydroxydehydroabietic acid (3) were isolated from the stem bark of Picea glehni, together with seven known diterpenoids-13-epimanoyl oxide (4), dehydroabietic acid (5), (11E)-14, 15-bisnor-8alpha-hydroxy-11-labden-13-one (6), abieta-8,11, 13-trien-7-one (7), 9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid (8), 9,10alpha-epoxy-9,10-seco-abieta-8,11,13-trien-18-oic acid (9), and methyl 15-hydroxy-7-oxo-dehydroabietate (10).
CONCLUSIONS:
Compounds 5-8 and 10 showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.
