6'-O-Cinnamoylharpagide
6'-O-Cinnamoylharpagide has anti-inflammatory activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Mol Biol Rep.2024, 51(1):117.
Chulalongkorn University2024, ssrn.4716057.
Chem Biol Interact.2019, 315:108910
Int J Mol Sci.2021, 22(2):770.
Revista Brasileira de Farmacognosia2024, 34:1276-1286.
Front Pharmacol.2020, 11:683.
Reprod Toxicol.2020, 96:1-10.
Separations2021, 8(6),80.
United States Patent Application2020, 20200038363
University of Guelph2021, 12.
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Planta Medica, 2012, 78(14).
Compounds form the roots of Harpagophytum procumbens and their anti-inflammatory activity.[Reference:
WebLink]
METHODS AND RESULTS:
Six known compounds: cinnamic acid (1), harpagoside, (2), 8-O-(cis-cinnamoyl)harpagide (3), acteoside (4), isoacteoside (5), and 6'-O-Cinnamoylharpagide (6) were isolated from the roots of Harpagophytum procumbens. The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR.
Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.
Nat Prod Res. 2009;23(13):1181-8.
A new iridoid glycoside from Scrophularia ningpoensis.[Pubmed:
19731136]
METHODS AND RESULTS:
A new iridoid glycoside, named 6'-O-Cinnamoylharpagide (1), has been isolated from the roots of Scrophularia ningpoensis (Scrophulariaceae) together with nine known compounds, harpagide (2), harpagoside (3), 8-O-feruloylharpagide (4), 8-O-(p-coumaroyl)harpagide (5), 6-O-methylcatalpol (6), aucubin (7), buergerinin B (8), teuhircoside (9) and 6-O-cinnamoyl-D-glucopyranose (10). Compound 10 was obtained as an inseparable mixture of 6-O-cinnamoyl-alpha-D-glucopyranose and 6-O-cinnamoyl-beta-D-glucopyranose at a ratio of 1 : 1, which is presumably formed by cleavage of compound 1.
CONCLUSIONS:
Their structures were elucidated on the basis of chemical and spectral analysis.
