5,5'-Dimethoxysecoisolariciresinol

Planta Med. 2010 Feb;76(3):294-7.

New secoisolariciresinol derivatives from Lindera obtusiloba stems and their neuroprotective activities.[Pubmed: 19708005 ]

METHODS AND RESULTS:
A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9'- O-di-(E)-feruloyl-meso-5,5'-Dimethoxysecoisolariciresinol (1) and 9,9'-O-di-(E)-sinapinoyl-meso-5,5'-Dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9'-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L. obtusiloba stems.
CONCLUSIONS:
Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.

Zhong Yao Cai. 2015 May;38(5):972-4.

Chemical Constitutes from Root of Artocarpus styracifolius.[Pubmed: 26767289]

To study the chemical constituents from root of Artocarpus styracifolius.
METHODS AND RESULTS:
Tne constituents were isolated from the root of Artocarpus styracifolius by column chromatography over silica gel, RP-18 silica gel, MCI GEL CHP-20P, macroporous resin HP-20, Sephadex LH-20, Toyopearl HW-40C and by preparative HPLC. Their structures were elucidated by analysis of physical and chemical properties and spectral data. RESULTS: Nine compounds were isolated and their structures were identified as p-hydroxy benzoic acid (1), syringic acid (2), 2,4-dihydroxy benzaldehyde (3), (+)-lyoniresinol (4), 5,5'-Dimethoxysecoisolariciresinol (5), (+)- syringaresinol (6), scopoletin (7), xylarolide (8) and trans-oxyresveratrol (9).
CONCLUSIONS:
Compounds 2, 5, 6 and 8 are isolated from Moraceae for the first time. Compounds 1, 4 and 7 are firstly characterized in the genus Artocarpus, compounds 3 and 9 are characterized in Artocarpus styracifolius for the first time.