5,5'-Dimethoxysecoisolariciresinol
5,5'-Dimethoxysecoisolariciresinol is a natural product from Podocarpus spicata.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Holistic Integrative Pharmacy2024, 5(1):45-55.
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Phytochemistry.2017, 141:162-170
Cell Death Differ.2021, 1-8.
Scientific World Journal.2014, 2014:654193
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Planta Med. 2010 Feb;76(3):294-7.
New secoisolariciresinol derivatives from Lindera obtusiloba stems and their neuroprotective activities.[Pubmed:
19708005 ]
METHODS AND RESULTS:
A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9'- O-di-(E)-feruloyl-meso-5,5'-Dimethoxysecoisolariciresinol (1) and 9,9'-O-di-(E)-sinapinoyl-meso-5,5'-Dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9'-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L. obtusiloba stems.
CONCLUSIONS:
Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.
Zhong Yao Cai. 2015 May;38(5):972-4.
Chemical Constitutes from Root of Artocarpus styracifolius.[Pubmed:
26767289]
To study the chemical constituents from root of Artocarpus styracifolius.
METHODS AND RESULTS:
Tne constituents were isolated from the root of Artocarpus styracifolius by column chromatography over silica gel, RP-18 silica gel, MCI GEL CHP-20P, macroporous resin HP-20, Sephadex LH-20, Toyopearl HW-40C and by preparative HPLC. Their structures were elucidated by analysis of physical and chemical properties and spectral data. RESULTS: Nine compounds were isolated and their structures were identified as p-hydroxy benzoic acid (1), syringic acid (2), 2,4-dihydroxy benzaldehyde (3), (+)-lyoniresinol (4), 5,5'-Dimethoxysecoisolariciresinol (5), (+)- syringaresinol (6), scopoletin (7), xylarolide (8) and trans-oxyresveratrol (9).
CONCLUSIONS:
Compounds 2, 5, 6 and 8 are isolated from Moraceae for the first time. Compounds 1, 4 and 7 are firstly characterized in the genus Artocarpus, compounds 3 and 9 are characterized in Artocarpus styracifolius for the first time.
