2beta-(Isobutyryloxy)florilenalin
2beta-(Isobutyryloxy)florilenalin induces apoptosis in human nasopharyngeal carcinoma CNE cells.
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Molecules. 2009 Jun 12;14(6):2135-46.
2beta-(Isobutyryloxy)florilenalin, a sesquiterpene lactone isolated from the medicinal plant Centipeda minima, induces apoptosis in human nasopharyngeal carcinoma CNE cells.[Pubmed:
19553887]
Centipeda minima is a medicinal plant reputed in China as a remedy for nasopharyngeal carcinoma (NPC).
METHODS AND RESULTS:
In this study, bioactivity-guided fractionation of the anti-NPC compound(s) from C. minima led to the isolation of 2beta-(Isobutyryloxy)florilenalin (IF), a sesquiterpene lactone. IF showed significant dose- and time- dependent inhibition on the growth of the human nasopharyngeal carcinoma epithelia cells (CNE). It induced apoptosis in CNE cells, as shown by the accumulation of sub-G1 cell population, DNA fragmentation and nuclear condensation, caspase-3 activation and PARP cleavage. Such induction was associated with the depletion of mitochondrial membrane potential (DeltaPsim) and the release of cytochrome c to cytosol to regulate the expression of Bcl-2 family proteins.
These activities led to the cleavage of caspases and the trigger of cell death process.
CONCLUSIONS:
Overall, IF in C. minima showed potent antiproliferative effect of C. minima on NPC cells, suggesting that the plant deserves more extensive investigation for its potential medicinal application.
