2',3'-Dihydroxy-4'-methoxyacetophenone
2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
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Bioorg Med Chem Lett. 2013 Dec 15;23(24):6732-6.
The ameliorating effects of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced memory impairment in mice and its neuroprotective activity.[Pubmed:
24210692]
We isolated 2,3-dihydroxy-4-methoxyacetophenone, a neuroprotective compound from Cynenchum paniculatum in our previous study.
METHODS AND RESULTS:
The present study was conducted to investigate the possible neuroprotective effect of 2,3-dihydroxy-4-methoxyacetophenone that has been previously isolated from Cynenchum paniculatum on hippocampal neuronal cell line, HT22 cells and its possible cognitive-enhancing effect on scopolamine-induced amnesia in mice. Neuroprotective effect against glutamate-induced neurotoxicity in HT22 cells was evaluated by MTT assay. Also, cognitive enhancing effect against scopolamine (1mg/kg, ip) induced learning and memory deficit was measured by Morris water maze test. Oral administered of 2,3-dihydroxy-4-methoxyacetophenone (1, 10, 20, 40 and 50mg/kg) to amnesic mice induced by scopolamine. In Morris water maze test, 2,3-dihydroxy-4-methoxyacetophenone (50mg/kg) improved the impairment of spatial memory induced by scopolamine. 2,3-Dihydroxy-4-methoxyacetophenone protect HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50 value: 10.94μM). Furthermore, 2,3-dihydroxy-4-methoxyacetophenone was found to inhibit [Ca(2+)] accumulation in HT22 cells and had antioxidantive activity. The results showed that 2,3-dihydroxy-4-methoxyacetophenone exert neuroprotective and cognitive-enhancing activities through its antioxidant activity.
CONCLUSIONS:
We suggest that 2,3-dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.
Planta Medica, 2012, 78(5):71.
2,3-dihydroxy-4-methoxyacetophenone Isolated from Cynanchum paniculatum Attenuates Scopolamine-induced Impairment of Spatial Memory in Mice.[Reference:
WebLink]
METHODS AND RESULTS:
We isolated 2,3-dihydroxy-4-methoxyacetophenone(2',3'-Dihydroxy-4'-methoxyacetophenone) from Cynenchum paniculatum which we have previously reported as having an neuroprotective effect. The objective of this study was to investigate the cognitive-enhancing effect of 2,3-dihydroxy-4-methoxyacetophenone on scopolamine-induced amnesia. SCOP (1 mg/kg, i.p.) induced a learning and memory deficit measured both during and after training 2,3-dihydroxy-4-methoxyacetophenone was orally administered to amnesic mice induced by scopolamine and the mice were then evaluated using the Morris water maze test. The results showed that 2,3-dihydroxy-4-methoxyacetophenone ameliorated scopolamine- induced amnesia based on the Morris water maze test.
CONCLUSIONS:
We suggest that 2,3-dihydroxy-4-methoxyacetophenone improve cognitive function and may be helpful for the treatment of Alzheimer's disease.
