2,3-Bis(3,4-dimethoxybenzyl)butyrolactone

2,3-Bis(3,4-dimethoxybenzyl)butyrolactone
Product Name 2,3-Bis(3,4-dimethoxybenzyl)butyrolactone
CAS No.: 25488-59-9
Catalog No.: CFN98281
Molecular Formula: C22H26O6
Molecular Weight: 386.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Targets: Sodium Channel | ATPase | Potassium Channel
Source: The barks of Pseudolarix kaempferi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
trans-2,3-Bis(3,4-dimethoxybenzyl)-gamma-butyrolactone is capable of inhibiting Na+,K+-ATPase activity with IC50 at a concentration less than 5 x 10(-4) M, it also shows [3H]ouabain displacement activity with IC50 at a concentration of 10(-4)-10(-3) M.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • ACS Omega.2022, 7(44):40009-40020.
  • Environ Toxicol.2021, 36(9):1848-1856.
  • Spectrochim Acta A2019, 210:372-380
  • J Ethnopharmacol.2017, 198:205-213
  • Processes 2021, 9(5),894.
  • ACS Omega.2024, 9(41):42227-42244.
  • Int J Mol Sci.2018, 19(9):E2825
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Pharmaceutics.2023, 15(9):2355.
  • Toxicol Res.2019, 35(4):371-387
  • Trachelogenin 4'-O-beta-gentiobioside

    Catalog No: CFN95235
    CAS No: 106647-13-6
    Price: $218/10mg
    Nortrachelogenin-8'-O-beta-glucoside

    Catalog No: CFN95234
    CAS No: 858127-38-5
    Price: $368/10mg
    Nortrachelogenin-5'-C-beta-glucoside

    Catalog No: CFN95251
    CAS No: 858127-39-6
    Price: $318/10mg
    Traxillaside

    Catalog No: CFN96608
    CAS No: 149415-62-3
    Price: Inquiry(manager@chemfaces.com)
    Trachelosiaside

    Catalog No: CFN89466
    CAS No: 106647-12-5
    Price: Inquiry(manager@chemfaces.com)
    Styraxlignolide F

    Catalog No: CFN92491
    CAS No: 823214-06-8
    Price: Inquiry(manager@chemfaces.com)
    2,3-Bis(3,4-dimethoxybenzyl)butyrolactone

    Catalog No: CFN98281
    CAS No: 25488-59-9
    Price: Inquiry(manager@chemfaces.com)
    Tupichilignan A

    Catalog No: CFN97182
    CAS No: 69586-96-5
    Price: Inquiry(manager@chemfaces.com)
    5-Acetoxymatairesinol dimethyl ether

    Catalog No: CFN97230
    CAS No: 74892-45-8
    Price: Inquiry(manager@chemfaces.com)
    Pluviatolide

    Catalog No: CFN92059
    CAS No: 28115-68-6
    Price: Inquiry(manager@chemfaces.com)
    Res Commun Chem Pathol Pharmacol. 1989 May;64(2):227-40.
    Endogenous digoxin-like activity of mammalian-lignans and their derivatives.[Pubmed: 2544967]
    A comparative study was made on the endogenous digoxin-like activity of sixteen mammalian-type lignan derivatives including enterolactone and enterodiol.
    METHODS AND RESULTS:
    Cross-reactivity to antidigoxin antibody, inhibition of dog kidney Na+,K+-ATPase, and ouabain displacing activity against [3H]ouabain binding to human erythrocytes on the part of these derivatives were examined and compared in all cases with that of ouabain. meso-2,3-Dibenzylbutane-1,4-diol (meso-HA-1) was found to possess the most potent cross-reactivity to antidigoxin antibody. Several lignans, particularly HA-1 (either meso or dl), dl-2,3-bis(3-methoxybenzyl)butane-1,4-diol(HA-4), dl-2,3-bis(3,4-dimethoxybenzyl)butane-1,4-diol(HA-10), dl-2,3-bis(3,4-dimethoxybenzyl)-1,4-dimethoxybutane(HA-11), and trans-2,3-bis(3,4-dimethoxybenzyl)-gamma-butyrolactone(HA-14) were capable of inhibiting Na+,K+-ATPase activity with IC50 at a concentration less than 5 x 10(-4) M. Meso-HA-1, HA-11 and HA-14 also showed [3H]ouabain displacement activity with IC50 at a concentration of 10(-4)-10(-3) M. These determinations of activity were made at doses 100-1000 times those of ouabain.
    CONCLUSIONS:
    The synthetic lignans are considered to derive in vivo from plant material usually present in fibrous food. Based on the data obtained, some lignans may possibly be endogenous digitalis-like substances.
    Tetrahedron: Asymmetry.1998 August;9(16):2827–2831.
    A chemoenzymatic synthesis of both enantiomers of a cis-lignan lactone.[Reference: WebLink]

    METHODS AND RESULTS:
    The stereoselective acetylation of meso-2,3-bis(3,4-dimethoxybenzyl)butanediol by vinyl acetate in the presence of Candida antarctica lipase in benzene gave the corresponding (+)-(2S,3R) monoester (ee ≥98%). Transesterification of meso-2,3-bis(3,4-dimethoxybenzyl)butyl diacetate, in the presence of the same enzyme, by ethanol in benzene/isopropyl ether gave the corresponding (−)-(2R,3S) monoester (ee ≥98%).
    CONCLUSIONS:
    Both enantiomers of the known cis-2,3-Bis(3,4-dimethoxybenzyl)butyrolactone were synthesized from these monoesters.
    2-O-cinnamoyl-beta-D-glucose

    Catalog No: CFN95111
    CAS No: N/A
    Price: $318/20mg
    Isorubrofusarin 10-gentiobioside

    Catalog No: CFN95119
    CAS No: 200127-93-1
    Price: $338/10mg
    3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol

    Catalog No: CFN95123
    CAS No: 1221686-60-7
    Price: $398/5mg
    Tigloylgomisin O

    Catalog No: CFN95237
    CAS No: 130855-74-2
    Price: $368/5mg
    Safflospermidine A

    Catalog No: CFN95255
    CAS No: 1111082-13-3
    Price: $413/5mg
    Bergamjuicin

    Catalog No: CFN95422
    CAS No: 2376307-20-7
    Price: $318/5mg
    12-Acetoxy ganoderic acid D

    Catalog No: CFN95535
    CAS No: N/A
    Price: $318/5mg
    Ganoderic acid GS-2

    Catalog No: CFN95549
    CAS No: 1206781-65-8
    Price: $413/5mg
    Irigenin 3'-O-glucoside

    Catalog No: CFN95578
    CAS No: N/A
    Price: $318/5mg
    11-Keto-ganoderic acid DM

    Catalog No: CFN95593
    CAS No: N/A
    Price: $413/5mg