1,5-Diphenylpentan-1-one
1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Toxicol In Vitro.2023, 93:105667.
Molecules.2019, 24(4):E744
Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
Life Sci.2022, 298:120488.
Eur J Pharmacol.2022, 917:174744.
Biol Pharm Bull.2017, 40(6):797-806
Srinagarind Medical Journal2017, 32(1)
Pharmacognosy Journal2019, 11,6:1235-1241
Int J Mol Sci.2018, 19(9):E2601
FEBS J.2022, 10.1111:febs.16676.
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Pest Manag Sci. 2001 Mar;57(3):307-10.
Activity of the botanical aphicides 1,5-diphenyl-1-pentanone and 1,5-diphenyl-2-penten-1-one on two species of Aphididnae.[Pubmed:
11455662]
1,5-Diphenyl-1-pentanone (1,5-Diphenylpentan-1-one, A) and 1,5-diphenyl-2-penten-1-one (B) are natural products extracted for the first time from Stellera chamaejasme.
METHODS AND RESULTS:
Laboratory bioassay showed that the two products have strong contact activity and very good anti-feedant activity against Aphis gossypii and Schizaphis graminum. Both products showed dose-dependent relationships for both forms of activity against the two aphids, the contact activity of B being about twice that of A. Both products were inferior to methomyl in contact activity but superior in anti-feedant activity against the two aphids.
CONCLUSIONS:
This is the first report of aphicidal activity in these two compounds, which may represent a new class of aphicide.
Chem Biol Drug Des. 2011 Jul;78(1):94-100.
Design, synthesis, and bioactivities screening of a diaryl ketone-inspired pesticide molecular library as derived from natural products.[Pubmed:
21457470]
METHODS AND RESULTS:
Three natural products, 1,5-Diphenylpentan-1-one, 1,5-diphenylpent-2-en-1-one, and 3-hydroxy-1,5-Diphenylpentan-1-one, with good insecticidal activities were extracted from Stellera chamaejasme L. Based on their shared diaryl ketone moiety as 'pharmacophores', a series of diaryl ketones were synthesized and tested for insecticidal activity, acetylcholinesterase inhibitory activity, and antifungal activity.
All synthesized compounds showed poor insecticidal and acetylcholinesterase inhibitory activities.
Compound III with a furyl ring showed strong activities against plant pathogenic fungi.
CONCLUSIONS:
The IC(50) of compound (E)-1-(2,4-dichlorophenyl)-3-(furan-2-yl)- -prop-2-en-1-one (III(2) ) was 1.20 mg/L against Rhizoctonia solani, suggesting its strong potential as a novel antifungal drug.
