1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol
1-(3,4-Dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol shows anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the minimum inhibitory concentrations (MICs) are in the range of 128-256 ug/ml.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Lat. Am. J. Pharm.,2009,28 (2): 279-83.
Diphenylpropanoids from Quisqualis indica Linn. and their Anti-staphylococcal Activity.[Reference:
WebLink]
METHODS AND RESULTS:
Four diphenylpropanoids- 1-(4-hydroxy-3-methoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy) propan-1-ol (1), 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol (2), 1-(3,4- dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ylacetate (3) and 1-(4-hydroxy-3,5- dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy) propan-1-ol (4) were isolated from the chloroform soluble fraction of a methanol extract of Quisqualis indica.
CONCLUSIONS:
The structures of these compounds were established unambiguously by MS and a series of 1D and 2D-NMR analyses.
