Immunomodulators

Chikusetsusaponin IVa
Catalog No: CFN92516

Chikusetsusaponin IVa is a novel AMPK activator, can induce insulin secretion from βTC3 cells via GPR40 mediated calcium and PKC pathways, may be developed into a new potential for therapeutic agent used in T2DM patients.Chikusetsusaponin IVa exerts antithrombotic effects, including minor hemorrhagic events.

Skimmianin
Catalog No: CFN92555

Skimmianine is a new inhibitor against the Leishmania APRT enzyme, it is also a strong acetylcholinesterase (AChE) inhibitor. Skimmianine has anti-inflammatory, immunomodulatory, and leishmanicidal properties, it has a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats.

Oxoglaucine
Catalog No: CFN90508

Oxoglaucine exerts immunomodulatory effect in vivo in a dose-dependent and protocol-dependent manner, it also exhibits significant antiplatelet aggregation activity against rabbit platelets induced by thrombin, arachidonic acid, collagen or platelet activating factor. Oxoglaucine and pachypodol are anti-picornavirus compounds, phosphatidylinositol 4-kinase III beta (PI4KB) as the direct target of them.

Periplocin
Catalog No: CFN90513

Periplocin has anti-cancer, and potent immunoregulatory effects, it induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine.

Demethylwedelolactone
Catalog No: CFN90521

Demethylwedelolactone has trypsin inhibitory effect, it exerts anti-invasive growth effect on breast cancer cells.