Immunomodulators

Phloretin
Catalog No: CFN97040

Phloretin may potentially be an immunomodulator by impairing the activation and function of DCs, it is effective in preventing estrogen deficiency-induced osteoclastogenic resorption. Phloretin has antimicrobial activity against the Gram negative bacteria Salmonella typhimurium ATCC 13311. It has a wide spectrum of targets including ASK-1-MAPK, Smac, capase.

Sarracine
Catalog No: CFN00309

Sarracine and neosarracine show immunomodulatory activities.

Neosarracine
Catalog No: CFN00314

1. Neosarracine and sarracine show immunomodulatory activities.

Quassin
Catalog No: CFN97246

Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion. Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity. It also exhibits P. falciparum inhibitory activity (IC50=0.06 micro g/ml, 0.15 micro M). Quassin possesses anti-anaemic property, it can significantly increase red blood cell count, pack cell volume and haemoglobin concentration.

Rutaecarpine
Catalog No: CFN97337

Rutaecarpine is an inhibitor of COX-2 with an IC50 value of 0.28 μM, and is also a potent inhibitor of CYP1A2. Rutaecarpine has anti-atherosclerosis, immunosuppressive, anti-inflammatory, gastroprotective, vasorelaxing, antihypertensive and anti-platelet effects. Rutaecarpine has positive inotropic and chronotropic effects on the guinea-pig isolated right atria, possible involvement of vanilloid receptors. Rutaecarpine may be useful in the prevention of ultraviolet A-induced photoaging, it inhibits ultraviolet A-induced reactive oxygen species generation, resulting in the enhanced expression of matrix metalloproteinase (MMP)-2 and MMP-9 in human skin cells.