Antiangiogenic

Chebulinic acid
Catalog No: CFN92296

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity; it also is a natural inhibitor of vascular endothelial growth factor-A mediated angiogenesis. Chebulinic acid has hypotensive, antioxidant, anti-HIV, and anti-ulcer activities. Chebulinic acid has inhibitory effect on erythroid differentiation likely through changing transcriptional activation of differentiation relative genes, it or other tannins might influence the efficiency of some anti-tumor drugs-induced differentiation or the hematopoiesis processes.

(-)-Lariciresinol
Catalog No: CFN92501

Lariciresinol administration can inhibit the tumor growth and tumor angiogenesis, conceivable importance of dietary lignan lariciresinol in inhibition of breast cancer development.

Purpurin
Catalog No: CFN92566

Purpurin is one of the natural colorants extracted from madder roots and other Rubiaceae family plants. Purpurin is a novel specific inhibitor of Adipocyte-derived leucine aminopeptidase, it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities.

10-Hydroxy-2-decenoic acid
Catalog No: CFN90512

10-Hydroxy-2-decenoic acid is a potential HDACI which inhibits the proliferation of FLS cells by PI3K-AKT pathway; it exerts an inhibitory effect on VEGF-induced angiogenesis, partly by inhibiting both cell proliferation and migration. 10-Hydroxy-2-decenoic acid activates AMPK, and insulin independently enhances glucose uptake following translocation of Glut4 to PM; it also can prevent UVA-induced damage and inhibit MMP-1 and MMP-3 expressions.

Acetylshikonin
Catalog No: CFN90523

Acetylshikonin has anti-cancer and anti-inflammatory activity, it is a novel general P450 inhibitor with IC50 values of 1.4-4.0 μM for all tested P450s. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC50 of over 20 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors. Certain shikonin derivatives(such as Acetylshikonin) act as modulators of the Nur77-mediated apoptotic pathway.