Antiangiogenic

Columbamine
Catalog No: CFN90581

Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity. It shows strong acetylcholinesterase (AChE) inhibitory activity with IC50 48.1 μM.

Tetrahydrocurcumin
Catalog No: CFN90583

Tetrahydrocurcumin can inhibit tumor angiogenesis, treat human breast cancer,and be a promising candidate for the prevention of CIPN by chemotherapeutic agents.Tetrahydrocurcumin exhibits protective effects against cisplatin-induced oxidative renal damage in rats by inhibiting cyclooxygenase-2 and caspase-3 activation; it has a protective effect over arsenic induced toxicity in rat.

Lupiwighteone
Catalog No: CFN96146

Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.

Isoxanthohumol
Catalog No: CFN90768

Isoxanthohumol is a polyphenol with antioxidant, anti-inflammatory, and antiangiogenic properties, seems to regulate in vivo vascular proliferation and stabilization and the EC-VSMC-inflammatory crosstalk. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).

Vanillyl alcohol
Catalog No: CFN93211

Vanillyl alcohol possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit the cytotoxicity and improved cell viability in 1-methyl-4-phenylpyridinium (MPP+)-induced MN9D dopaminergic cells, it also can attenuate the elevation of reactive oxygen species (ROS) levels, decrease in the Bax/Bcl-2 ratio and poly (ADP-ribose) polymerase proteolysis.