Anti-proliferation

Chonglou Saponin VII
Catalog No: CFN97162

Chonglou saponin VII shows inhibitory effects on cell proliferation.

17alpha-Neriifolin
Catalog No: CFN97195

17alpha-Neriifolin and 17alpha-Deacetyltanghinin have little anti-proliferative activity, indicating that the 17beta configuration is critical for the anti-proliferative activity of these compounds.

9-Oxo-10,11-dehydroageraphorone
Catalog No: CFN97272

9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M phase.

Ethyl gallate
Catalog No: CFN97323

Ethyl gallate has anti-cancer, antioxidant activities, it may be an alternative class of vasopressors for use in septic shock. Ethyl gallate can treat acute lung injury (ALI) mainly by reducing the total cells and infiltration of activated polymorphonuclear leukocytes (PMNs). Ethyl gallate inhibits Akt , NF-κB p-65, Bcl-2/Bax, and mRNA levels of MMP-2 and MMP-9.

Rocaglamide
Catalog No: CFN97339

Rocaglamides are potent natural anticancer products that inhibit proliferation of various cancer cells at nanomolar concentrations, it prevents tumor growth and sensitize resistant cancer cells to apoptosis by blocking the MEK-ERK-eIF4 pathway. Rocaglamides can suppress the PMA-induced expression of NF-kappaB target genes and sensitize leukemic T cells to apoptosis induced by TNFalpha, cisplatin, and gamma-irradiation, suggests that rocaglamide derivatives could serve as lead structures in the development of anti-inflammatory and tumoricidal drugs. Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas.