Anti-proliferation

Typhaneoside
Catalog No: CFN98146

Typhaneoside is possibly the main active component in the bioactive fraction of Shaofu Zhuyu decoction, Shaofu Zhuyu decoction may have direct inhibitory effects on the contractility of the mice uterus. It has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cells(HUASMC) with a wide range of effective dose but the effect is started slowly.

Ophiopogonin D
Catalog No: CFN98156

Ophiopogonin D plays a protective role as an effective antioxidant in H2O2-induced endothelial injury, it can attenuate doxorubicin-induced autophagic cell death by relieving mitochondrial damage in vitro and in vivo, it can be therefore developed as a novel drug for the therapy of cardiovascular disorders. Ophiopogonin D and spicatoside A can increase mucin production and secretion, by directly acting on airway epithelial cells, they could be as expectorants in diverse inflammatory pulmonary diseases. Ophiopogonin D inhibits MCF-7 cell growth via the induction of cell cycle arrest at the G2/M phase.

Loureirin B
Catalog No: CFN98173

Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway, loureirin B can suppress tetrodotoxin-sensitive (TTX-S) voltage-gated sodium currents in a dose-dependent way.

Heraclenol
Catalog No: CFN98402

Heraclenol is a germination inhibitor in the parsley seeds. It has anti-inflammatory properties against the ear edema in mice produced by TPA. Heraclenol and heraclenin inhibit the proliferation of melanoma cells and cell cycle at G2/M at concentrations of 0.1-1.0 uM.

Gartanin
Catalog No: CFN98428

Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1αsignaling pathways. Gartanin possesses potent antioxidant, anti-inflammatory, antifungal and antineoplastic properties, it has anti-proliferation effect in T98G cells, which is most likely via cell cycle arrest modulated by autophagy, which is regulated by PI3K/Akt/mTOR signalling pathway, while its anti-migration effect is most likely via suppression of MMP-2/-9 activity which is involved in MAPK signalling pathway.