Antagonists

Kuwanon H
Catalog No: CFN90835

Kuwanon H, and possibly kuwanon G also, are specific antagonists for the gastrin-releasing peptide (GRP) -preferring receptor and can be useful for studying the physiological and pathological role of GRP.

6-Deoxyjacareubin
Catalog No: CFN96276

6-Deoxyjacareubin possesses significant antioxidant activities, it also exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.6-Deoxyjacareubin is antifungal against Cladosporium cucumerinum, while it shows differing degrees of inhibition of monoamine oxidase A and B. 6-Deoxyjacareubin shows strong platelet activating factor (PAF) receptor binding inhibitory effects using rabbit platelets with IC50 values of 29.0 microM, suggests that xanthones can represent a new class of natural PAF receptor antagonists.

Piperenone
Catalog No: CFN96283

Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.

(-)-Corlumine
Catalog No: CFN96340

Corlumine exhibits spasmolytic and GABA antagonist activity.

Futoenone
Catalog No: CFN96370

Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2′ site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.