Vibralactone D
Vibralactones D shows weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).
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Chem Pharm Bull (Tokyo). 2010 Jan;58(1):113-6.
Vibralactones D-F from cultures of the basidiomycete Boreostereum vibrans.[Pubmed:
20045978]
Three new metabolites, Vibralactone D, vibralactone E, vibralactone F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans.
METHODS AND RESULTS:
The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).
