Schisanlignone A
Schisanlignone A and Schisanlignone B show a significant activity against Leukaemia P-388 cell (IG(50) =10 and 40ug/mL, respectively) in vitro.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Acta Chimica Sinica, 1991,49 (4) :412-416.
Isolation and Structures of Schisanlignone A, B and Butyryl Binankadsurin A.[Reference:
WebLink]
METHODS AND RESULTS:
Three new lignan compounds named Schisanlignone A (4), Schisanlignone B(5) and butyryl binankadsurin A (6) along with three known lignans, binankadsurin A(1), acetyl binankadsurin A (2) and angeloyl binankadsurin A (3), were isolated from the seeds of a kadsura sp. collected in Rongshui county of Guangxi, China.
Their structure elucidation including absolute configurations relieg on chemical conversions of 4 into (+)-deoxyschizandrin (4a), of 5 into 4, and of 6 into 1 besides the routine spectral analysis.
CONCLUSIONS:
4 and 5 show a significant activity against Leukaemia P-388 cell (IG_(50) 10 and 40 μg/mL respectively) in vitro.
Nat Prod Res. 2008;22(15):1344-9.
Kadsutherin D, a new dibenzocyclooctadiene lignan from Kadsura species.[Pubmed:
19023792]
METHODS AND RESULTS:
A new dibenzocyclooctadiene lignan, kadsutherin D (1), together with 12 known lignans, kadsurin (2), heteroclitin C (3), interiotherin C (4), Schisanlignone A (5), binankadsurin A (6), angeloyl binankadsurin A (7), gomisin U (8), heteroclitin D (9), interiorin (10), schiarisanrin C (11), heteroclitin G (12) and meso-dihydroguaiaretic acid (13) were isolated from the stems of Kadsura species. Their structures were elucidated by spectroscopic methods including 2D-NMR techniques.
