Sanggenone H
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α and IL-1β and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Metabolites.2019, 9(11):E271
J Nat Med.2022, 76(1):59-67.
PLoS One.2017, 12(3):e0173585
Antioxidants (Basel).2023, 12(12):2131.
Vietnam Journal of Science2022,64(2):69-75.
Molecules.2017, 22(12)
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Int J Mol Sci.2020, 21(9):3144.
Mol Pharm.2018, 15(8):3285-3296
FASEB J.2022, 36(7):e22387.
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J Nat Prod. 2014 Jun 27;77(6):1297-303.
Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra.[Pubmed:
24901948 ]
Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), Sanggenone H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10).
CONCLUSIONS:
The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.
