Rosamultic acid
Rosamultic acid is a class of triterpenes with α-glucosidase inhibitory activity.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Journal of Plant Growth Regulation2022, 10705-2.
Applied Biological Chemistry2021, 64(4)
Front Cell Dev Biol.2021, 9:588093.
Bio-protocol2018, 9(14):e3301
PLoS One.2022, 17(4):e0267007.
Plant Sci.2021, 313:111069.
ACS Synth Biol.2020, 9(9):2282-2290.
Metabolites2022, 12(6),507.
Nutrients.2018, 10(10)
Heliyon.2023, 9:e21652.
Related and Featured Products
Phytomedicine. 2015 Aug 15;22(9):796-806.
Antiproliferative activity of rosamultic acid is associated with induction of apoptosis, cell cycle arrest, inhibition of cell migration and caspase activation in human gastric cancer (SGC-7901) cells.[Pubmed:
26220626]
The objective of the present research work demonstrated the antiproliferative and apoptotic activity of Rosamultic acid, a natural triterpenoid, in human gastric cancer (SGC-7901) cells. Its effect on cellular morphology, cell cycle arrest, DNA fragmentation and expression levels of caspase-3, caspase-8 and caspase-9 were also determined.
METHODS AND RESULTS:
Antiproliferative activity of Rosamultic acid was evaluated by MTT assay. Phase contrast, fluorescence microscopy as well as flow cytometry using Hoechst 33342, acridine orange/ethidium bromide and Annexin V-FITC as cellular probes were used to evaluate the induction of apoptosis by Rosamultic acid. Protein level expressions were analyzed by western blot analysis. The results revealed that Rosamultic acid induced dose-dependent as well as time dependent cytotoxic effects in SGC-7901 gastric cancer cells. It also led to a reduction in clonogenic activity along with inhibiting the cell migration. Characteristic features of apoptosis induced by Rosamultic acid were observed and quantified. Cell cycle arrest at sub-G1 phase was induced by Rosamultic acid along with downregulation of expression levels of CDK4, CDK6 and cyclin D1. Rosamultic acid also significantly led to the activation of caspase-3, -8 and -9 during the 48 h treatment along with cleaving PARP in a dose-dependent manner. DNA fragmentation following Rosamultic acid treatment was also observed in these cells.
CONCLUSIONS:
The current study strongly reveals that Rosamultic acid inhibits gastric cancer proliferation by inducing apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases.
