Precocene II
Precocene II , an insect growth regulator, it inhibits the production of juvenile hormone (JH) in insects, it is highly toxic to adult female Rhodnius and treatment of newly emerged females prevented oogenesis. Precocene II is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
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Chem Biol Interact. 1989;71(2-3):187-99.
Alteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels.[Pubmed:
2598296]
Precocene II (6,7-dimethoxy-2,2-dimethyl-2H-benzo[b]pyran), an insect growth regulator that is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats. This investigation was conducted to evaluate the effects of modulation of hepatic glutathione levels on the toxicity of Precocene II.
METHODS AND RESULTS:
Administration of a toxic dose of Precocene II (175 mg/kg) to male Sprague-Dawley rats rapidly depleted hepatic GSH, produced histopathological changes in the liver, and induced increases in serum aminotransferase activity. Concurrent administration of the cysteine pro-drug L-2-oxothiazolidine-4-carboxylic acid (OTC) prevented these toxic effects of Precocene II. In contrast, pretreatment of rats with DL-buthionine-SR-sulfoximine (BSO), an inhibitor of glutathione synthesis, potentiated the toxicity of an otherwise non-toxic dose of Precocene II (100 mg/kg).
CONCLUSIONS:
These results indicate that glutathione is important for protection from Precocene II-induced hepatotoxicity.
Indian J Exp Biol. 2011 Aug;49(8):600-8.
Sensitivity of last larval stadium of Chrysomya megacephala (Fabricius) to anti-allatin ageratochromene Precocene II.[Pubmed:
21870428]
METHODS AND RESULTS:
Treatment of early and late third instar larvae of economically important insect C. megacephala with the ageratochromene Precocene II resulted into precocious metamorphosis.
The other effects included mortality, production of pupal-adult mosaics, reduction in percentage of adult emergence and formation of non-viable deformed adults that died after a few hours of emergence.
CONCLUSIONS:
The application of Precocene II adversely hampered the normal growth, development and metamorphosis of the insect and the results show that Precocene II has vast potential for excellent control of this insect of medico-veterinary importance and can be used in insect pest management programs.
J Insect Physiol. 2005 Apr;51(4):411-6.
Effect of precocene II on fatty acid metabolism in the pea aphid, Acyrthosiphon pisum, under cold stress.[Pubmed:
15890184]
METHODS AND RESULTS:
Pea aphids, Acyrthosiphon pisum (Harris), reared at 10 degrees C contain higher levels of fatty acids than those reared at 25 degrees C. This is primarily the result of an accumulation of triacylglycerols containing myristic acid. When aphids reared at 25 degrees C were transferred to 10 degrees C there was a gradual increase in triacylglycerol content that reached a maximum at 16 days post-transfer. Treatment of aphids with Precocene II prior to transfer to 10 degrees C blocked the accumulation of fatty acids including myristic acid. A single application of 2 microg Precocene II/aphid or two applications of 0.5 microg Precocene II/ aphid administered on consecutive days resulted in aphids moved to 10 degrees C maintaining the same fatty acid profile as aphids maintained at 25 degrees C. Aphids that were treated with Precocene II and maintained at 25 degrees C did not show changes in fatty acid profiles. Rearing aphids at 10 degrees C resulted in lower rates of reproduction and lower total numbers of progeny with longer longevity. Treatment with Precocene II significantly decreased the total number of progeny produced at both temperatures.
CONCLUSIONS:
Precocene II did not reduce life span of aphids reared at 25 degrees C, however, the life span of treated aphids reared at 10 degrees C was decreased. The mechanism by which Precocene II prevents the accumulation of myristic acid in aphids reared at 10 degrees C remains to be determined.
Am J Trop Med Hyg. 1982 Mar;31(2):416-20.
The effects of precocene II on reproduction and development of triatomine bugs (Reduviidae: Triatominae).[Pubmed:
7041667]
Precocene II is a botanically derived chemical that inhibits the production of juvenile hormone (JH) in insects. The effects of this anti-JH compound on molting and growth by Rhodnius prolixus and Triatoma dimidiata and reproduction in R. prolixus were tested and the efficacy of Precocene II as a fumigant was assessed.
METHODS AND RESULTS:
Precocene II induced precocious metamorphosis in both species when applied by either contact exposure or fumigation, and this effect could be prevented by juvenile hormone replacement therapy. The dosage effective in inducing precocious metamorphosis in T. dimidiata was similar to the EC50 previously reported for R. prolixus. The morphology of precocious adultoid T. dimidiata of different instars was similar to Rhodnius adultoids of corresponding instars. However, T. dimidiata was more sensitive than Rhodnius to the molt-inhibiting effects of Precocene II. Rhodnius nymphs were fully susceptible to the anti-JH action of precocene when exposed for 24 hours one week before feeding.
CONCLUSIONS:
Precocene II was highly toxic to adult female Rhodnius and treatment of newly emerged females prevented oogenesis.
