Phyperunolide E
Phyperunolide E is a natural product from Physalis peruviana L.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Pharmacognosy Journal, 2021, 13(5).
J Sci Food Agric.2023, 103(1):213-220.
Evidence-based Compl.&Alternative Med.2023, 5417813
Int J Mol Sci.2023, 24(14):11496.
Plant Cell Tiss Org2020, 1-16
BMC Complement Med Ther. 2020, 20(1):91.
Biomolecules2021, 11(10),1513.
Hortic Res.2023, 10(4):uhad039.
Asian Journal of Chemistry2014, 26(22):7811-7816
Curr Issues Mol Biol.2022, 44(5):2300-2308.
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Food Chemistry, 2009, 116(2):462-469.
New cytotoxic withanolides from Physalis peruviana.[Reference:
WebLink]
METHODS AND RESULTS:
Investigation of the extracts of Physalis peruviana L. has led to the isolation of seven new withanolides, phyperunolide A (1), phyperunolide B (2), phyperunolide C (3), phyperunolide D (4), peruvianoxide (5), Phyperunolide E (16), and phyperunolide F (17) together with ten known withanolides. The structure and absolute stereochemistry of all compounds were elucidated on the basis of CD and NMR spectral analysis, respectively.
CONCLUSIONS:
Compounds 1, 6, 7, and 9 showed cytotoxicity against lung cancer (A549), breast cancer (MDA-MB-231 and MCF7), and liver cancer (Hep G2 and Hep 3B) cancer cell lines. The presence of 5β,6β-epoxy-2-en-1-ones in withanolides is greatly helpful in cytotoxicity, it is a key known important factor to cytotoxicity; however, interestingly, the unusual 5-chloride withanolide, 9, displayed significant activity.
