Neuchromenin
(-)-Neuchromenin is an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 ug/ml.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Natural Organic Compounds Symposium keynote speech (43), 2001: 497-502.
84(P-41) Determination of the Absolute Configuration of Microbial Metabolites, (-)-Neuchromenin, (-)-Nocardione A and (-)-Nocardione B by Their Synthesis[Reference:
WebLink]
In 1996 (-)-Neuchromenin (1) was isolated from the culture broth of Eupenicillium javanicum var. meloforme PF1181 as an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 μg/ml. Its structure was deduced as 1 by extensive spectral analysis, although its absolute configuration remained unknown.
METHODS AND RESULTS:
In order to settle that stereochemical problem, we undertook the synthesis of both the enantiomers of Neuchromenin using both the enantiomers of known aldehyde (11). By synthesizing both (R) and (S) enantiomers of Neuchromenin, we found (S) enantiomer to be identical with the naturally occurring (-)-Neuchromenin. In 2000 two new furano-o-naphthoquinones, (-)-nocardione B (2) and (-)-nocardione A (3) were isolated as new tyrosine phosphatase inhibitors with moderate antifungal and cytotoxic activities. Due to the scarcity of the materials, their absolute configuration remained unknown. In order to solve this problem, we undertook a synthesis of optically active nocardiones with known absolute configuration. (R)-(+)-Nocardione B (2) and (S)-(-)-nocardione A (3) were synthesized by starting from the commercially available enantiomers of propylene oxide and 5-benzyloxy (or methoxy)-1-tetralone.
CONCLUSIONS:
As a result, the absolute configuration of the naturally occurring (-)-nocardione A and (-)-nocardione B was established as S.
